Bhawan J, Petry J, Rybak M E
Dermatopathology Section, Boston University School of Medicine, MA 02118.
J Cutan Pathol. 1989 Jun;16(3):158-63. doi: 10.1111/j.1600-0560.1989.tb00032.x.
Extravasation of doxorubicin in skin and soft tissue causes necrosis and ulceration. These ulcers form slowly and heal with great difficulty. The cause of ulceration is not known. Histologic changes in two patients suggest that an exaggeration of interface dermatitis like epidermal changes may be responsible for epidermal necrosis. This process may be enhanced or complicated by ischemic changes caused by thrombosis of the venous tributaries at the site of the intravenous infusions. Squamous syringometaplasia seen in both cases can be confused with squamous cell carcinoma. Dermal changes mimic those seen in radiation injury.
多柔比星在皮肤和软组织中的外渗会导致坏死和溃疡。这些溃疡形成缓慢且愈合极为困难。溃疡的病因尚不清楚。两名患者的组织学变化提示，类似界面性皮炎的表皮变化过度可能是表皮坏死的原因。静脉输注部位静脉分支血栓形成所导致的缺血性改变可能会加重这一过程或使其复杂化。两例中均可见的鳞状汗腺化生可能会与鳞状细胞癌相混淆。真皮变化与放射损伤所见相似。
