Digital Healthcare Research Center, Institute of Information Technology and Convergence, Pukyong National University, Busan 48513, Republic of Korea.
Industry 4.0 Convergence Bionics Engineering, Department of Biomedical Engineering, Pukyong National University, Busan 48513, Republic of Korea.
Adv Colloid Interface Sci. 2023 Nov;321:103013. doi: 10.1016/j.cis.2023.103013. Epub 2023 Oct 7.
Hydroxyapatite (HAp), a well-known biomaterial, has witnessed a remarkable evolution over the years, transforming from a simple biocompatible substance to an advanced functional material with a wide range of applications. This abstract provides an overview of the significant advancements in the field of HAp and its journey towards becoming a multifunctional material. Initially recognized for its exceptional biocompatibility and bioactivity, HAp gained prominence in the field of bone tissue engineering and dental applications. Its ability to integrate with surrounding tissues, promote cellular adhesion, and facilitate osseointegration made it an ideal candidate for various biomedical implants and coatings. As the understanding of HAp grew, researchers explored its potential beyond traditional biomaterial applications. With advances in material synthesis and engineering, HAp began to exhibit unique properties that extended its utility to other disciplines. Researchers successfully tailored the composition, morphology, and surface characteristics of HAp, leading to enhanced mechanical strength, controlled drug release capabilities, and improved biodegradability. These modifications enabled the utilization of HAp in drug delivery systems, biosensors, tissue engineering scaffolds, and regenerative medicine applications. Moreover, the exceptional biomineralization properties of HAp allowed for the incorporation of functional ions and molecules during synthesis, leading to the development of bioactive coatings and composites with specific therapeutic functionalities. These functionalized HAp materials have demonstrated promising results in antimicrobial coatings, controlled release systems for growth factors and therapeutic agents, and even as catalysts in chemical reactions. In recent years, HAp nanoparticles and nanostructured materials have emerged as a focal point of research due to their unique physicochemical properties and potential for targeted drug delivery, imaging, and theranostic applications. The ability to manipulate the size, shape, and surface chemistry of HAp at the nanoscale has paved the way for innovative approaches in personalized medicine and regenerative therapies. This abstract highlights the exceptional evolution of HAp, from a traditional biomaterial to an advanced functional material. The exploration of novel synthesis methods, surface modifications, and nanoengineering techniques has expanded the horizon of HAp applications, enabling its integration into diverse fields ranging from biomedicine to catalysis. Additionally, this manuscript discusses the emerging prospects of HAp-based materials in photocatalysis, sensing, and energy storage, showcasing its potential as an advanced functional material beyond the realm of biomedical applications. As research in this field progresses, the future holds tremendous potential for HAp-based materials to revolutionize medical treatments and contribute to the advancement of science and technology.
羟基磷灰石（HAp）是一种众所周知的生物材料，多年来经历了显著的发展，从一种简单的生物相容性物质转变为具有广泛应用的先进功能材料。本文概述了 HAp 领域的重大进展及其向多功能材料发展的历程。HAp 最初因其出色的生物相容性和生物活性而受到关注，在骨组织工程和牙科应用领域得到了广泛应用。其与周围组织整合、促进细胞黏附和促成骨整合的能力使其成为各种生物医学植入物和涂层的理想选择。随着对 HAp 认识的不断深入，研究人员开始探索其在传统生物材料应用之外的潜力。随着材料合成和工程技术的进步，HAp 开始表现出独特的性能，使其在其他学科中的应用得到扩展。研究人员成功地调整了 HAp 的组成、形态和表面特性，从而提高了机械强度、控制药物释放能力和改善生物降解性。这些改进使得 HAp 能够用于药物输送系统、生物传感器、组织工程支架和再生医学应用。此外，HAp 的出色生物矿化特性允许在合成过程中掺入功能离子和分子，从而开发出具有特定治疗功能的生物活性涂层和复合材料。这些功能化 HAp 材料在抗菌涂层、生长因子和治疗剂的控释系统以及化学反应中的催化剂等方面表现出了有前景的结果。近年来，由于其独特的物理化学性质和靶向药物输送、成像和治疗应用的潜力，HAp 纳米粒子和纳米结构材料成为研究的焦点。能够在纳米尺度上操纵 HAp 的大小、形状和表面化学性质为个性化医学和再生疗法的创新方法铺平了道路。本文重点介绍了 HAp 从传统生物材料向先进功能材料的非凡发展历程。新型合成方法、表面改性和纳米工程技术的探索扩展了 HAp 应用的范围，使其能够整合到从生物医药到催化等多个领域。此外，本文还讨论了基于 HAp 的材料在光催化、传感和储能方面的新兴前景，展示了其作为除生物医学应用领域之外的先进功能材料的潜力。随着该领域研究的进展，基于 HAp 的材料在医疗治疗中的应用具有巨大的潜力，可以为科学技术的进步做出贡献。
