Poo Chin Long, Lau Mei Siu, Nasir Nur Liana Md, Nik Zainuddin Nik Aina Syazana, Rahman Mohd Rahimi Ashraf Abd, Mustapha Kamal Siti Khadijah, Awang Norizah, Muhammad Hussin
Herbal Medicine Research Centre, Institute for Medical Research, National Institutes of Health, Ministry of Health Malaysia, Shah Alam 40170, Selangor, Malaysia.
Curr Issues Mol Biol. 2024 Oct 16;46(10):11460-11502. doi: 10.3390/cimb46100682.
Liver diseases cause millions of deaths globally. Current treatments are often limited in effectiveness and availability, driving the search for alternatives. Herbal preparations offer potential hepatoprotective properties. Disrupted gut microbiota is linked to liver disorders. This scoping review aims to explore the effects of herbal preparations on hepatoprotective mechanisms, particularly in the context of non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and hepatic steatosis, with a focus on gut microbiota modulation. A systematic search was performed using predetermined keywords in four electronic databases (PubMed, Scopus, EMBASE, and Web of Science). A total of 55 studies were included for descriptive analysis, covering study characteristics such as disease model, dietary model, animal model, intervention details, comparators, and study outcomes. The findings of this review suggest that the hepatoprotective effects of herbal preparations are closely related to their interactions with the gut microbiota. The hepatoprotective mechanisms of herbal preparations are shown through their effects on the gut microbiota composition, intestinal barrier, and microbial metabolites, which resulted in decreased serum levels of liver enzymes and lipids, improved liver pathology, inhibition of hepatic fatty acid accumulation, suppression of inflammation and oxidative stress, reduced insulin resistance, and altered bile acid metabolism.
肝脏疾病在全球范围内导致数百万人死亡。目前的治疗方法在有效性和可及性方面往往存在局限，这促使人们寻找替代方法。草药制剂具有潜在的肝脏保护特性。肠道微生物群紊乱与肝脏疾病有关。本综述旨在探讨草药制剂对肝脏保护机制的影响，特别是在非酒精性脂肪性肝病（NAFLD）、非酒精性脂肪性肝炎（NASH）和肝脂肪变性的背景下，重点关注肠道微生物群的调节。使用预定关键词在四个电子数据库（PubMed、Scopus、EMBASE和Web of Science）中进行了系统检索。总共纳入了55项研究进行描述性分析，涵盖疾病模型、饮食模型、动物模型、干预细节、对照物和研究结果等研究特征。本综述的结果表明，草药制剂的肝脏保护作用与其与肠道微生物群的相互作用密切相关。草药制剂的肝脏保护机制通过其对肠道微生物群组成、肠道屏障和微生物代谢产物的影响得以体现，这些影响导致血清肝酶和脂质水平降低、肝脏病理改善、肝脂肪酸积累受到抑制、炎症和氧化应激得到抑制、胰岛素抵抗降低以及胆汁酸代谢改变。
