Department of Healthcare Administration, Asia University, Taichung 413305, Taiwan.
Department of Performance, Taipei Medical University-Shuang Ho Hospital, Ministry of Health and Welfare, Taipei 115204, Taiwan.
Curr Oncol. 2024 Oct 12;31(10):6144-6154. doi: 10.3390/curroncol31100458.
Lung cancer patients suffer from numerous symptoms that impact their quality of life. This study aims to identify the symptom burden on quality of life in lung cancer patients. This survey used a structured questionnaire to collect data from 8 March 2021 to 12 May 2021. Patient demographic information was collected. The data on symptom burden and quality of life (QOL) of patients were obtained from the QLQ-C30 and the QLQ-LC13. The stepwise multiple regression analysis was used to estimate lung cancer-related symptom burden in relation to quality of life. The study included 159 patients with lung cancer who completed the questionnaire. The mean age of the patients was 63.12 ± 11.4 years, and 64.8% of them were female. The Global Quality of Life score of the QLQ-C30 was 67.87 ± 22.24, and the top five lung cancer-related symptoms were insomnia, dyspnea, and fatigue from the QLQ-C30, and coughing and dyspnea from the QLQ-LC13. The multiple regression analysis showed that appetite loss was the most frequently associated factor for global QOL (β = -0.32; adjusted R: 27%) and cognitive function (β = -0.15; adjusted R: 11%), while fatigue was associated with role function (β = -0.35; adjusted R: 43%), emotional function (β = -0.26; adjusted R: 9%), and social function (β = -0.26; adjusted R: 27%). Dyspnea was associated with physical function (β = -0.45; adjusted R: 42%). Appetite loss, fatigue, and dyspnea were the main reasons causing symptom burdens on quality of life for lung cancer patients. Decreasing these symptoms can improve the quality of life and survival for patients with lung cancer.
肺癌患者患有多种影响其生活质量的症状。本研究旨在确定肺癌患者的症状负担对生活质量的影响。本调查采用结构化问卷，于 2021 年 3 月 8 日至 5 月 12 日期间收集数据。收集患者的人口统计学信息。通过 QLQ-C30 和 QLQ-LC13 获得患者的症状负担和生活质量（QOL）数据。采用逐步多元回归分析来估计与生活质量相关的肺癌相关症状负担。该研究纳入了 159 名完成问卷的肺癌患者。患者的平均年龄为 63.12±11.4 岁，其中 64.8%为女性。QLQ-C30 的总体生活质量评分（Global Quality of Life score）为 67.87±22.24，QLQ-C30 中排名前五的肺癌相关症状为失眠、呼吸困难和疲劳，QLQ-LC13 中为咳嗽和呼吸困难。多元回归分析显示，食欲下降是全球 QOL（β=-0.32；调整 R：27%）和认知功能（β=-0.15；调整 R：11%）最常相关的因素，而疲劳与角色功能（β=-0.35；调整 R：43%）、情绪功能（β=-0.26；调整 R：9%）和社会功能（β=-0.26；调整 R：27%）相关。呼吸困难与身体功能（β=-0.45；调整 R：42%）相关。食欲下降、疲劳和呼吸困难是导致肺癌患者生活质量症状负担的主要原因。减轻这些症状可以提高肺癌患者的生活质量和生存率。
