Bondar Laura Ioana, Osser Brigitte, Osser Gyongyi, Mariș Mariana Adelina, Piroș Ligia Elisaveta, Almășan Robert, Toth Csongor, Miuta Caius Calin, Marconi Gabriel Roberto, Bouroș-Tataru Ana-Liana, Măduța Victor, Tăședan Dana, Popescu Mircea Ioachim
Doctoral School of Biomedical Sciences, University of Oradea, 410087 Oradea, Romania.
Department of Biology and Life Sciences, "Vasile Goldiș" Western University of Arad, 310048 Arad, Romania.
Clin Pract. 2024 Oct 17;14(5):2166-2186. doi: 10.3390/clinpract14050171.
This study investigates the association between depression and ischemic heart disease (IHD), conditions that often coexist and complicate patient management. Understanding the impact of demographic factors, risk factors, symptoms, and medical approaches in these patients is essential to develop effective clinical strategies. The aim of this study is to investigate how demographic characteristics, risk factors, symptoms, and treatment methods differ between patients with depression alone and those with both depression and IHD. It seeks to identify how these factors influence patient outcomes, providing insights to improve management and treatment approaches for this complex patient group. : This cross-sectional study included a sample of 332 patients diagnosed with depression, with a specific subgroup consisting of individuals who also had comorbid IHD. Statistical analyses were performed to compare the patients with depression, focusing on those with IHD. Data on demographic characteristics (e.g., gender, environment, social status), risk factors (e.g., hypertension, diabetes), symptom severity, and treatments (e.g., antidepressants, antipsychotics, anxiolytics, hypnotics) were analyzed. The study also evaluated the frequency of cardiac examinations and emergency hospitalizations. Significant demographic differences were found between the two groups. Patients with both depression and IHD had higher rates of hypertension and diabetes mellitus and experienced more severe depressive symptoms, including reduced mood, energy, and activity levels. The treatment patterns were similar in terms of antidepressant use, but the IHD group had a higher use of antipsychotics, anxiolytics, and hypnotics. Additionally, these patients required more cardiac examinations and emergency hospitalizations. Comorbidity between depression and IHD presents complex clinical challenges, and it is crucial to implement an integrated management approach that addresses both mental and physical health. This study highlights the need for comprehensive therapeutic strategies to improve the quality of life and outcomes for patients with these coexisting conditions.
本研究调查抑郁症与缺血性心脏病（IHD）之间的关联，这两种病症常同时存在并使患者管理复杂化。了解这些患者的人口统计学因素、风险因素、症状及医疗方法的影响对于制定有效的临床策略至关重要。本研究的目的是调查单纯抑郁症患者与同时患有抑郁症和缺血性心脏病的患者在人口统计学特征、风险因素、症状及治疗方法上有何不同。研究旨在确定这些因素如何影响患者预后，为改善这一复杂患者群体的管理和治疗方法提供见解。：这项横断面研究纳入了332名被诊断为抑郁症的患者样本，其中一个特定亚组由同时患有缺血性心脏病的个体组成。进行了统计分析以比较抑郁症患者，重点是患有缺血性心脏病的患者。分析了人口统计学特征（如性别、环境、社会地位）、风险因素（如高血压、糖尿病）、症状严重程度及治疗（如抗抑郁药、抗精神病药、抗焦虑药、催眠药）的数据。该研究还评估了心脏检查和急诊住院的频率。两组之间存在显著的人口统计学差异。同时患有抑郁症和缺血性心脏病的患者高血压和糖尿病的发病率更高，且经历更严重的抑郁症状，包括情绪、精力和活动水平下降。在抗抑郁药使用方面，治疗模式相似，但缺血性心脏病组使用抗精神病药、抗焦虑药和催眠药的比例更高。此外，这些患者需要更多的心脏检查和急诊住院。抑郁症和缺血性心脏病的共病带来了复杂的临床挑战，实施兼顾精神和身体健康的综合管理方法至关重要。本研究强调了需要全面的治疗策略来提高这些共存病症患者的生活质量和预后。
