Ferreira Monica, Oliveira Mario, Laranjo Sergio, Rocha Isabel
Faculdade de Medicina and Centro Cardiovascular da Universidade de Lisboa-CCUL, Universidade de Lisboa, 1649-004 Lisbon, Portugal.
Cardiology Department, Hospital de Santa Marta, Unidade Local de Saúde de S. José, 1150-199 Lisbon, Portugal.
Biology (Basel). 2024 Sep 25;13(10):761. doi: 10.3390/biology13100761.
Sleep is a complex biobehavioural process essential for overall health, with various dimensions including duration, continuity, timing, and satisfaction. This study investigated the intricate relationships between common sleep disorders such as insomnia and obstructive sleep apnoea (OSA) and their impact on atrial fibrillation (AF), a prevalent arrhythmia with significant health implications. Using a comprehensive review of the current literature, this study examined the pathophysiological mechanisms linking sleep disorders to cardiovascular risks, focusing on autonomic nervous system disturbances, inflammation, and oxidative stress associated with OSA. These findings indicate that sleep disorders significantly elevate the risk of AF through mechanisms such as increased sympathetic activity and structural cardiac remodelling. Additionally, this study highlights the potential benefits of treating sleep disorders, particularly with continuous positive airway pressure (CPAP) therapy, in reducing AF recurrence and improving cardiovascular outcomes. This conclusion emphasises the importance of integrated therapeutic approaches that address both sleep disorders and AF to enhance patient outcomes and quality of life. Future research should explore these connections to develop more effective and holistic treatment strategies.
睡眠是一个对整体健康至关重要的复杂生物行为过程，具有包括持续时间、连续性、时间安排和满意度等多个维度。本研究调查了常见睡眠障碍（如失眠和阻塞性睡眠呼吸暂停（OSA））之间的复杂关系及其对心房颤动（AF）的影响，心房颤动是一种普遍存在的心律失常，对健康有重大影响。通过对当前文献的全面综述，本研究检查了将睡眠障碍与心血管风险联系起来的病理生理机制，重点关注与OSA相关的自主神经系统紊乱、炎症和氧化应激。这些发现表明，睡眠障碍通过增加交感神经活动和心脏结构重塑等机制显著提高了房颤风险。此外，本研究强调了治疗睡眠障碍的潜在益处，特别是通过持续气道正压通气（CPAP）治疗，以减少房颤复发并改善心血管结局。这一结论强调了综合治疗方法的重要性，即同时解决睡眠障碍和房颤问题，以提高患者的治疗效果和生活质量。未来的研究应探索这些联系，以制定更有效和全面的治疗策略。
