Pechroj Sirintip, Kaewkod Thida, Sattayawat Pachara, Inta Angkhana, Suriyaprom Sureeporn, Yata Teerapong, Tragoolpua Yingmanee, Promputtha Itthayakorn
Department of Biology, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand.
Multidisciplinary and Interdisciplinary School, Chiang Mai University, Chiang Mai 50200, Thailand.
Biology (Basel). 2024 Oct 11;13(10):815. doi: 10.3390/biology13100815.
This study investigates the therapeutic potential of extracts, focusing on the 95% ethanol (95E) extract and its nanoemulsified form, against oral pathogens and their bioactive effects. The findings demonstrate potent antibacterial activity against and , essential for combating periodontal diseases, and significant anti-biofilm properties crucial for plaque management. Additionally, the extracts exhibit promising inhibitory effects on α-glucosidase enzymes, indicating potential for diabetes management through glucose metabolism regulation. Their anti-inflammatory properties, evidenced by reduced nitric oxide production, underscore their potential for treating oral infections and inflammation. Notably, the nanoemulsified 95E extract shows higher efficiency than the conventional extract, suggesting a multifunctional treatment approach for periodontal issues and metabolic disorders. These results highlight the enhanced efficacy of the nanoemulsified extract, proposing it as an effective treatment modality for periodontal disease in diabetic patients. This research offers valuable insights into the development of innovative drug delivery systems using natural remedies for improved periodontal care in diabetic populations.
本研究调查了提取物的治疗潜力，重点关注95%乙醇（95E）提取物及其纳米乳化形式对口腔病原体的作用及其生物活性效应。研究结果表明，其对牙龈卟啉单胞菌和具核梭杆菌具有强大的抗菌活性，这对对抗牙周疾病至关重要，同时还具有显著的抗生物膜特性，这对牙菌斑管理至关重要。此外，提取物对α-葡萄糖苷酶表现出有前景的抑制作用，表明通过调节葡萄糖代谢来管理糖尿病具有潜力。其抗炎特性通过一氧化氮生成减少得到证明，突出了它们在治疗口腔感染和炎症方面的潜力。值得注意的是，纳米乳化的95 E提取物比传统提取物显示出更高的效率，表明对牙周问题和代谢紊乱有多功能治疗方法。这些结果突出了纳米乳化提取物的增强疗效，提出其作为糖尿病患者牙周疾病的有效治疗方式。本研究为利用天然药物开发创新药物递送系统以改善糖尿病患者的牙周护理提供了有价值的见解。
