Antifungal Susceptibility Data and Epidemiological Distribution of spp.: An In Vitro Five-Year Evaluation at University Hospital Policlinico of Catania and a Comprehensive Literature Review.

BACKGROUND

Invasive fungal infections represent a concerning healthcare issue, with spp. reported as the main aetiological agent. spp. bloodstream infections show high mortality rates, indicating increasing antifungal-resistance episodes as a contributing feature. Despite the global prevalence of , non- species emerged as significant in the last decades.

METHODS

The present manuscript reports a five-year evaluation on spp. bloodstream isolates and their antifungal susceptibility profiles, aiming to enrich the literature and epidemiological data.

RESULTS

According to the gathered data, antifungal-resistance cases remained uncommon. However, the study revealed rare resistance phenotypes such as a single case of pan-echinocandin resistance .

CONCLUSIONS

Finally, a comprehensive review of spp. antifungal resistance integrates the data, emphasizing the extreme species-specific variability and the consequent importance of always providing species identification.