Calvo Maddalena, Scalia Guido, Trovato Laura
Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy.
U.O.C. Laboratory Analysis Unit, A.O.U. Policlinico "G. Rodolico-San Marco" Catania, 95123 Catania, Italy.
Antibiotics (Basel). 2024 Sep 24;13(10):914. doi: 10.3390/antibiotics13100914.
Invasive fungal infections represent a concerning healthcare issue, with spp. reported as the main aetiological agent. spp. bloodstream infections show high mortality rates, indicating increasing antifungal-resistance episodes as a contributing feature. Despite the global prevalence of , non- species emerged as significant in the last decades.
The present manuscript reports a five-year evaluation on spp. bloodstream isolates and their antifungal susceptibility profiles, aiming to enrich the literature and epidemiological data.
According to the gathered data, antifungal-resistance cases remained uncommon. However, the study revealed rare resistance phenotypes such as a single case of pan-echinocandin resistance .
Finally, a comprehensive review of spp. antifungal resistance integrates the data, emphasizing the extreme species-specific variability and the consequent importance of always providing species identification.
侵袭性真菌感染是一个令人担忧的医疗问题， spp. 被报道为主要病原体。 spp. 血流感染显示出高死亡率，表明抗真菌耐药性事件增加是一个促成因素。尽管 在全球普遍存在，但在过去几十年中，非 物种也变得很重要。
本手稿报告了对 spp. 血流分离株及其抗真菌药敏谱的五年评估，旨在丰富文献和流行病学数据。
根据收集的数据，抗真菌耐药病例仍然不常见。然而，该研究揭示了罕见的耐药表型，例如一例泛棘白菌素耐药 。
最后，对 spp. 抗真菌耐药性的全面综述整合了这些数据，强调了极端的物种特异性变异性以及始终提供物种鉴定的重要性。
