Beaumont Alexander J, Campbell Amy K, Unnithan Viswanath B, Oxborough David, Grace Fergal, Knox Allan, Sculthorpe Nicholas F
School of Science, Technology and Health, York St. John University, York YO31 7EX, UK.
Institute of Clinical Exercise and Health Sciences, School of Health and Life Sciences, University of the West of Scotland, Hamilton G72, 0LH, UK.
J Cardiovasc Dev Dis. 2024 Oct 12;11(10):321. doi: 10.3390/jcdd11100321.
Age-related differences in twist may be mitigated with exercise training, although this remains inconclusive. Moreover, temporal left ventricular (LV) systolic twist mechanics, including early-systolic (twist), and beyond peak twist (twist) alone, have not been considered. Therefore, further insights are required to ascertain the influence of age and training status on twist mechanics across systole. Forty males were included and allocated into 1 of 4 groups based on age and training status: young recreationally active (Y, n = 9; 28 ± 5 years), old recreationally active (O, n = 10; 68 ± 6 years), young trained (Y, n = 10; 27 ± 6 years), and old trained (O, n = 11, 64 ± 4 years) groups. Two-dimensional speckle-tracking echocardiography was performed to determine LV twist mechanics, including twist, twist, and total twist (twist), by considering the nadir on the twist time-curve during early systole. Twist was calculated by subtracting twist from their peak values. LV twist was higher in older than younger men ( = 0.036), while twist was lower in the trained than recreationally-active ( = 0.004). Twist is underestimated compared with twist ( < 0.001), and when early-systolic mechanics were considered, to calculate twist, the age effect ( = 0.186) was dampened. LV twist was higher in older than younger age, with lower twist in exercise-trained than recreationally-active males. Twist is underestimated when twist is not considered, with novel observations demonstrating that the age effect was dampened when considering twist. These findings elucidated a smaller age effect when early phases of systole are considered, while lower LV systolic mechanics were observed in older aged trained than recreationally-active males.
尽管运动训练对扭转的年龄相关差异的影响尚无定论，但可能会有所减轻。此外，尚未单独考虑左心室（LV）收缩期扭转力学的时间变化，包括收缩早期（扭转）和超过峰值扭转（扭转）。因此，需要进一步深入研究以确定年龄和训练状态对整个收缩期扭转力学的影响。纳入了40名男性，并根据年龄和训练状态将其分为4组中的1组：年轻的休闲活跃组（Y，n = 9；28±5岁）、年长的休闲活跃组（O，n = 10；68±6岁）、年轻的训练组（Y，n = 10；27±6岁）和年长的训练组（O，n = 11，64±4岁）。通过二维斑点追踪超声心动图来确定左心室扭转力学，包括扭转、扭转和总扭转（扭转），方法是考虑收缩早期扭转时间曲线上的最低点。扭转通过从其峰值中减去扭转来计算。年长男性的左心室扭转高于年轻男性（P = 0.036），而训练组的扭转低于休闲活跃组（P = 0.004）。与扭转相比，扭转被低估（P < 0.001），并且当考虑收缩早期力学来计算扭转时，年龄效应（P = 0.186）减弱。年长男性的左心室扭转高于年轻男性，运动训练男性的扭转低于休闲活跃男性。当不考虑扭转时，扭转被低估，新的观察结果表明，考虑扭转时年龄效应减弱。这些发现表明，当考虑收缩期早期阶段时，年龄效应较小，而在年长的训练男性中观察到的左心室收缩力学低于休闲活跃男性。
