Choi Jae Hyung, Kim Joo Young, Lee Ki Rim, Lee Gyeong Yun, Hong Mineui, Hwang Hye Won, Lee Moo Yeol, Kim Mi Kyung, Hong Soon Auck
Department of Physiology, College of Medicine, Chung-Ang University, Seoul 06974, Republic of Korea.
Department of Pathology, College of Medicine, Chung-Ang University, Seoul 06974, Republic of Korea.
J Pers Med. 2024 Sep 27;14(10):1033. doi: 10.3390/jpm14101033.
: Distal bile duct cancer is an aggressive malignancy. Tumor-infiltrating immune cells (TIICs) in the tumor microenvironment are crucial for predicting prognosis in various cancers. In this study, we analyzed TIICs based on CD11b, CD163, and CD8 expression, and evaluated their association with clinicopathologic factors and prognosis in distal bile duct cancer. A total of 90 patients who underwent curative resection for distal bile duct cancer were enrolled. We analyzed CD11b+ tumor-infiltrating myeloid cells (TIMs), CD163+ tumor-infiltrating macrophages (TAMs), and CD8+ tumor-infiltrating lymphocytes (TILs) using immunohistochemistry and tissue microarrays. The correlation between TIICs and clinicopathologic characteristics was assessed. Low levels of CD11b+ TIMs ( < 0.001) and high levels of CD8+ TILs ( = 0.003) were significantly associated with improved overall survival (OS). A combined low level of CD11b+ TIMs and high level of CD8+ TILs was identified as an independent favorable prognostic factor (hazard ratio, 0.159; confidence interval, 0.061-0.410; < 0.001). CD11b+ TIMs play a crucial role in the tumor microenvironment and the prognosis of distal bile duct cancer. The combined analysis of CD11b+ TIMs and CD8+ TILs can predict survival in patients with distal bile duct cancer.
远端胆管癌是一种侵袭性恶性肿瘤。肿瘤微环境中的肿瘤浸润免疫细胞（TIICs）对于预测各种癌症的预后至关重要。在本研究中，我们基于CD11b、CD163和CD8的表达分析了TIICs，并评估了它们与远端胆管癌临床病理因素及预后的相关性。共有90例接受了远端胆管癌根治性切除术的患者入组。我们使用免疫组织化学和组织芯片分析了CD11b +肿瘤浸润髓样细胞（TIMs）、CD163 +肿瘤浸润巨噬细胞（TAMs）和CD8 +肿瘤浸润淋巴细胞（TILs）。评估了TIICs与临床病理特征之间的相关性。低水平的CD11b + TIMs（<0.001）和高水平的CD8 + TILs（= 0.003）与总体生存期（OS）的改善显著相关。CD11b + TIMs低水平和CD8 + TILs高水平的组合被确定为独立的有利预后因素（风险比，0.159；置信区间，0.061 - 0.410；<0.001）。CD11b + TIMs在肿瘤微环境和远端胆管癌的预后中起关键作用。CD11b + TIMs和CD8 + TILs的联合分析可以预测远端胆管癌患者的生存期。
