Maghiar Laura, Naghi Petronela, Zaha Ioana Alexandra, Sandor Mircea, Bodog Alin, Sachelarie Liliana, Vieriu Georgiana, Stefan Liana, Huniadi Anca, Hurjui Loredana Liliana
Calla-Infertility Diagnostic and Treatment Center, Constantin A. Rosetti Street, 410103 Oradea, Romania.
Faculty of Medicine and Pharmacy, University of Oradea, 1st December Square 10, 410073 Oradea, Romania.
J Pers Med. 2024 Oct 9;14(10):1045. doi: 10.3390/jpm14101045.
(1) Background: Does the variation in sequential development times of embryos, observed through time-lapse monitoring, between the two study groups play a role in predicting pregnancy success? (2) Methods: The prospective double-arm study was to identify the morphokinetic parameters specific to embryos that were capable of implanting and were conducted on 89 embryos cultured in the Esco Miri time-lapse incubator, divided into two groups: Lot A, consisting of 57 embryos that successfully implanted and resulted in life birth rate (LBR), and Lot B (NLB), comprising 32 embryos that did not implant, leading to a negative beta-hCG outcome. (3) Results: Baseline characteristics, including female age, were not found to be statistically significant ( > 0.01). In contrast, there is a highly statistically significant difference concerning oocytes ( = 0.0029). Morphokinetic variables represented by sequential culture times were not statistically significant ( > 0.01) when comparing the two groups. However, the negative mean differences between these parameters suggest that the times for Lot A are better (shorter) than those for Lot B. While not statistically significant, these differences may still have practical significance. In the case of grading, the difference is considered to be extremely statistically significant ( < 0.01). (4) Conclusions: Although there are no statistically significant differences in sequential timings ( > 0.01) between the two groups, there are parameters indicating predictive potential for exploring pregnancy in embryo morphokinetics.
(1) 背景：通过延时监测观察到的两个研究组胚胎序贯发育时间的差异，在预测妊娠成功方面是否起作用？(2) 方法：这项前瞻性双臂研究旨在确定能够着床的胚胎特有的形态动力学参数，研究在Esco Miri延时培养箱中培养的89个胚胎上进行，分为两组：A组，由57个成功着床并导致活产率（LBR）的胚胎组成；B组（未着床组，NLB），包含32个未着床、导致β-hCG结果为阴性的胚胎。(3) 结果：包括女性年龄在内的基线特征在统计学上无显著差异（>0.01）。相比之下，卵母细胞方面存在高度统计学显著差异（=0.0029）。比较两组时，以序贯培养时间表示的形态动力学变量在统计学上无显著差异（>0.01）。然而，这些参数之间的负平均差异表明A组的时间更好（更短）于B组。虽然在统计学上不显著，但这些差异可能仍具有实际意义。在分级方面，差异被认为具有极高的统计学显著性（<0.01）。(4) 结论：虽然两组之间的序贯时间在统计学上无显著差异（>0.01），但在胚胎形态动力学中存在一些参数表明具有探索妊娠的预测潜力。
