Aldulaijan Sarah, Alruwili Raghad, Almulaify Rawan, Alhassan Fatimah A, Al-Dulaijan Yousif A, Alshahrani Faris A, Mokeem Lamia, Gad Mohammed M, Melo Mary Anne S, Balhaddad Abdulrahman A
Chemistry Department, College of Science, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia.
College of Dentistry, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia.
J Funct Biomater. 2024 Oct 18;15(10):310. doi: 10.3390/jfb15100310.
() adhering to denture-based resins (DBRs) is a known cause of denture stomatitis. A new approach to prevent denture stomatitis is to include antimicrobial substances within DBRs. Here, we examined the mechanical performance and antifungal properties of DBRs containing benzyldimethyldodecyl ammonium chloride (CBDMA-Cl) as an antimicrobial compound. CBDMA-Cl is a quaternary ammonium compound, and its antifungal properties have never been investigated when combined with dental acrylic resin. Therefore, we modified a commercially available heat-polymerized acrylic DBR to contain 3 and 5 wt.% of CBDMA-Cl. Unmodified DBR was used as a control group. Specimens were prepared using the conventional heat processing method. The specimen's flexural strength, elastic modulus, microhardness, and surface roughness were evaluated. biofilm was grown on the specimens and assessed via colony-forming units (CFUs) and scanning electron microscopy (SEM). In silico molecular docking was applied to predict the potential CBDMA-Cl inhibition activity as an antifungal drug. The 3% CBDMA-Cl DBR demonstrated antifungal activities without a deterioration effect on the mechanical performance. SEM images indicated fewer colonies in DBR containing CBDMA-Cl, which can be a potential approach to managing denture stomatitis. In conclusion, CBDMA-Cl is a promising antifungal agent for preventing and treating denture stomatitis.
（）附着在义齿基托树脂（DBR）上是义齿性口炎的一个已知病因。预防义齿性口炎的一种新方法是在DBR中加入抗菌物质。在此，我们研究了含有苄基二甲基十二烷基氯化铵（CBDMA-Cl）作为抗菌化合物的DBR的机械性能和抗真菌特性。CBDMA-Cl是一种季铵化合物，当它与牙科丙烯酸树脂结合时，其抗真菌特性从未被研究过。因此，我们对市售的热聚合丙烯酸DBR进行改性，使其含有3重量%和5重量%的CBDMA-Cl。未改性的DBR用作对照组。使用传统的热加工方法制备标本。评估标本的弯曲强度、弹性模量、显微硬度和表面粗糙度。在标本上培养生物膜，并通过菌落形成单位（CFU）和扫描电子显微镜（SEM）进行评估。应用计算机分子对接来预测CBDMA-Cl作为抗真菌药物的潜在抑制活性。含3%CBDMA-Cl的DBR表现出抗真菌活性，且对机械性能没有恶化影响。SEM图像显示含CBDMA-Cl的DBR中菌落较少，这可能是一种治疗义齿性口炎的潜在方法。总之，CBDMA-Cl是一种有前途的预防和治疗义齿性口炎的抗真菌剂。
