DeRuyter Emily, Subramaniam Kuttichantran, Wisely Samantha M, Morris J Glenn, Lednicky John A
Department of Environmental and Global Health, College of Public Health and Health Professions, University of Florida, Gainesville, FL 32610, USA.
Emerging Pathogens Institute, University of Florida, Gainesville, FL 32610, USA.
Pathogens. 2024 Sep 26;13(10):831. doi: 10.3390/pathogens13100831.
A novel jeilongvirus was identified through next-generation sequencing in cell cultures inoculated with spleen and kidney extracts. The spleen and kidney were obtained from a rodent (cotton mouse) found dead in the city of Gainesville, in North-Central Florida, USA. Jeilongviruses are paramyxoviruses of the subfamily that have been found in bats, cats, and rodents. We designated the virus we discovered as Gainesville rodent jeilong virus 1 (GRJV1). Preliminary results indicate that GRJV1 can complete its life cycle in various human, non-human primate, and rodent cell lines, suggesting that the virus has a generalist nature with the potential for a spillover event. The early detection of endemic viruses circulating within hosts in North-Central Florida can significantly enhance surveillance efforts, thereby bolstering our ability to monitor and respond to potential outbreaks effectively.
通过对接种脾脏和肾脏提取物的细胞培养物进行下一代测序，鉴定出一种新型杰隆病毒。脾脏和肾脏取自美国佛罗里达州中北部盖恩斯维尔市发现的一只死亡啮齿动物（棉鼠）。杰隆病毒是副粘病毒亚科的病毒，已在蝙蝠、猫和啮齿动物中发现。我们将发现的病毒命名为盖恩斯维尔啮齿动物杰隆病毒1（GRJV1）。初步结果表明，GRJV1可以在各种人类、非人类灵长类动物和啮齿动物细胞系中完成其生命周期，这表明该病毒具有广泛的宿主适应性，有可能引发跨物种传播事件。对佛罗里达州中北部宿主中流行的地方性病毒进行早期检测，可以显著加强监测工作，从而增强我们有效监测和应对潜在疫情的能力。
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