Biała Martyna, Babicki Mateusz, Malchrzak Wojciech, Janiak Sandra, Gajowiak Dominik, Żak Alan, Kłoda Karolina, Gibas Piotr, Ledwoch Justyna, Myśliwiec Anna, Kopyt Daria, Węgrzyn Anna, Knysz Brygida, Leśnik Patrycja
Department of Infectious Diseases, Liver Diseases and Acquired Immune Deficiences, Wroclaw Medical University, 51-149 Wroclaw, Poland.
Department of Family Medicine, Faculty of Medicine, Wroclaw Medical University, 50-367 Wroclaw, Poland.
Pathogens. 2024 Sep 28;13(10):846. doi: 10.3390/pathogens13100846.
is responsible for 20-30% of pharyngitis in children and 5-15% in adults. The ineffective treatment of group A Streptococcus (GAS) infections can result in postinfectious sequelae. This study aims to evaluate the frequency of GAS pharyngitis and assess the management of patients with pharyngitis and antibiotic use. We conducted a multicenter, retrospective analysis of medical records from nine primary care centers in Poland. The study enrolled 1949 medical records of patients (children 67.4%, adults 32.6%). An infection of , based on a rapid strep test, was diagnosed in 830 patients (42.6%). In the comprehensive study group of 1949 patients, 1054 (54.1%) were given antibiotics. Notably, 224 patients had a negative rapid strep test result but still received antibiotic treatment, underscoring the complexity of treatment decisions. The most commonly used antibiotics were oral penicillin V in 431 cases (41%) and amoxicillin in 219 cases (20.8%). We observed no significant difference between positive rapid strep test results and patients' sociodemographic data and comorbidities. The prevalence of GAS was 42.6% in the analyzed records of patients with pharyngitis, and 54.1% were prescribed antibiotics. Antibiotics were overprescribed for sore throats. Strategies are needed to promote rational antibiotic use.
它导致儿童咽炎的20%-30%，成人咽炎的5%-15%。A组链球菌（GAS）感染治疗不当可导致感染后后遗症。本研究旨在评估GAS咽炎的发生率，并评估咽炎患者的管理及抗生素使用情况。我们对波兰9个初级保健中心的病历进行了多中心回顾性分析。该研究纳入了1949份患者病历（儿童占67.4%，成人占32.6%）。基于快速链球菌检测，830例患者（42.6%）被诊断感染。在1949例患者的综合研究组中，1054例（54.1%）接受了抗生素治疗。值得注意的是，224例患者快速链球菌检测结果为阴性，但仍接受了抗生素治疗，这凸显了治疗决策的复杂性。最常用的抗生素是口服青霉素V，共431例（41%），阿莫西林219例（20.8%）。我们观察到快速链球菌检测阳性结果与患者的社会人口统计学数据及合并症之间无显著差异。在分析的咽炎患者病历中，GAS的患病率为42.6%，54.1%的患者被开具了抗生素。治疗咽喉痛时抗生素存在过度使用的情况。需要采取策略来促进抗生素的合理使用。
