Lorenzo-Hernández Elizabeth, Rivas-Ruiz Francisco, Del Arco-Jiménez Alfonso
Internal Medicine Department, Costa del Sol University Hospital, A-7, Km 187, 29603 Marbella, Malaga, Spain.
Research Unit, Costa del Sol University Hospital, A-7, Km 187, 29603 Marbella, Malaga, Spain.
Pathogens. 2024 Sep 29;13(10):847. doi: 10.3390/pathogens13100847.
This work aims to assess the impact of the COVID-19 pandemic on the mortality and incidence of complications in patients with bacteraemia due to (BSA). All episodes of BSA at the Costa del Sol University Hospital (Marbella, Spain) were recorded during the acute phase of the COVID-19 pandemic (March 2020-March 2022) and compared with those in a previous period (February 2018-February 2020). Demographic, clinical and prognostic variables were recorded. The outcomes were measured as 14- and 30-day mortality and the incidence of complications/death. Mortality during the pandemic was 28.7% at 14 days and 35% at 30 days, while in the pre-pandemic group, it was 18.9% and 23.3%, respectively. For overall complications/deaths, the incidence rate was higher in the pandemic group, with 42.7%. No significant differences were observed between groups. Seventeen patients with COVID-19 were identified, with mortality rates of 64.7% and 70.6% at 14 and 30 days. Multivariate analysis established the presence of sepsis at diagnosis as a predictor of mortality, but not BSA, during the pandemic phase. In conclusion, BSA is a disease with high mortality, which was slightly higher during the pandemic phase. No differences were found in adherence to the bundle in our centre.
这项研究旨在评估2019冠状病毒病（COVID-19）大流行对因[未提及具体病因，推测文本有误，可能是血流感染（BSA）应为血流感染（bacteremia）]导致的菌血症患者死亡率和并发症发生率的影响。在COVID-19大流行的急性期（2020年3月至2022年3月），记录了西班牙马贝拉太阳海岸大学医院所有的血流感染病例，并与之前时期（2018年2月至2020年2月）的病例进行比较。记录了人口统计学、临床和预后变量。结果指标为14天和30天死亡率以及并发症/死亡发生率。大流行期间14天死亡率为28.7%，30天死亡率为35%，而大流行前组分别为18.9%和23.3%。对于总体并发症/死亡情况，大流行组的发生率更高，为42.7%。两组之间未观察到显著差异。确定了17例COVID-19患者，14天和30天死亡率分别为64.7%和70.6%。多变量分析确定，在大流行阶段，诊断时存在脓毒症是死亡率的预测因素，而血流感染不是。总之，血流感染是一种死亡率很高的疾病，在大流行阶段略高。在我们中心，在遵循集束治疗方面未发现差异。
