Previti Annalisa, Biondi Vito, Sicuso Diego Antonio, Pugliese Michela, Passantino Annamaria
Department of Veterinary Sciences, University of Messina, 98168 Messina, Italy.
Pathogens. 2024 Oct 14;13(10):901. doi: 10.3390/pathogens13100901.
In canine leishmaniosis (CanL), complex interactions between the parasites and the immunological background of the host influence the clinical presentation and evolution of infection and disease. Therefore, the potential use of nutraceuticals as immunomodulatory agents becomes of considerable interest. Some biological principles, mainly derived from plants and referred to as plant-derived nutraceuticals, are considered as supplementation for spp. infection. This study provides a systematic review regarding the use of nutraceuticals as a treatment using a text mining (TM) and topic analysis (TA) approach to identify dominant topics of nutritional supplements in leishmaniosis-based research, summarize the temporal trend in topics, interpret the evolution within the last century and highlight any possible research gaps. Scopus database was screened to select 18 records. Findings revealed an increasing trend in research records since 1994. TM identified terms with the highest weighted frequency and TA highlighted the main research areas, namely "Nutraceutical supports and their anti-inflammatory/antioxidant properties", "AHCC and nucleotides in CanL", "Vit. D3 and Leishmaniosis", "Functional food effects and Leishmaniosis" and "Extract effects and Leishmaniosis". Despite the existing academic interest, there are only a few studies on this issue so far, which reveals a gap in the literature that should be filled.
在犬利什曼病（CanL）中，寄生虫与宿主免疫背景之间的复杂相互作用会影响感染和疾病的临床表现及发展。因此，营养保健品作为免疫调节剂的潜在用途备受关注。一些主要源自植物且被称为植物源营养保健品的生物活性成分，被认为可用于辅助治疗利什曼原虫感染。本研究采用文本挖掘（TM）和主题分析（TA）方法，对营养保健品在利什曼病治疗中的应用进行了系统综述，以确定基于利什曼病研究中营养补充剂的主要主题，总结主题的时间趋势，解读上个世纪内的研究演变，并突出任何可能存在的研究空白。通过筛选Scopus数据库，共选出18条记录。研究结果显示，自1994年以来研究记录呈上升趋势。文本挖掘确定了加权频率最高的术语，主题分析突出了主要研究领域，即“营养保健品支持及其抗炎/抗氧化特性”、“犬利什曼病中的AHCC和核苷酸”、“维生素D3与利什曼病”、“功能性食品作用与利什曼病”以及“提取物作用与利什曼病”。尽管目前已有学术关注，但迄今为止关于该问题的研究仍较少，这表明文献中存在有待填补的空白。
