从 spp. 海绵中分离得到新的 Discorhabdin D 类似物。
New Discorhabdin D Analogues from spp. Sponges.
机构信息
Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21701-1201, United States.
Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, United States.
出版信息
J Nat Prod. 2024 Nov 22;87(11):2640-2648. doi: 10.1021/acs.jnatprod.4c01036. Epub 2024 Oct 25.
Chemical profiles of and were investigated, resulting in the isolation of five new discorhabdin D derivatives and -. Their planar structures were solved by combination of NMR and HR-MS, while -based configurational analysis, computational techniques, and semisynthetic methods were used for the establishment of their absolute configurations. New natural products were tested for their growth inhibitory activity against the NCI-60 human tumor cell line panel, and two compounds and showed low micromolar potency.
对 和 进行了化学成分研究，分离得到了五个新的 discorhabdin D 衍生物 和 -。通过 NMR 和 HR-MS 的组合确定了它们的平面结构，而 - 的构型分析、计算技术和半合成方法则用于确定它们的绝对构型。对新的天然产物进行了对 NCI-60 人肿瘤细胞系的生长抑制活性测试，两种化合物 和 表现出低微摩尔活性。
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