Schallhorn Steven C, Fernández Joaquín, Kaymak Hakan, Gerlach Mario, Kirchner Friedrich O
From the Department of Ophthalmology, University of California, San Francisco, San Francisco, California (Schallhorn); Carl Zeiss Meditec, Inc., Dublin, California (Schallhorn); Department of Ophthalmology of VITHAS Almería Hospital, Qvision, Almería, Spain (Fernández); Internationale Innovative Ophthalmochirurgie GbR, Duesseldorf, Germany (Kaymak); Institute of Experimental Ophthalmology, Saarland University, Homburg, Germany (Kaymak); Carl Zeiss Meditec AG, Berlin, Germany (Gerlach, Kirchner).
J Cataract Refract Surg. 2025 Feb 1;51(2):133-140. doi: 10.1097/j.jcrs.0000000000001576.
To assess the reliability of a new virtual intraocular lens (IOL) implantation device to predict the outcomes of a trifocal IOL.
Clinical sites in Spain and Germany.
Prospective multicenter study.
Preoperative measurements obtained by the virtual implantation of AT LISA tri 839MP IOL with Virtual IOL (VirtIOL) device were compared with postoperative (month 3) outcomes after the IOL implantation. The evaluated metrics were defocus curve, contrast sensitivity (CS) (both in photopic conditions), and visual phenomena (visual angle size of burst and annular pattern) in mesopic conditions.
45 presbyopic noncataract patients (mean age 56.16 ± 5.03 years) were included in this study. The VirtIOL device reasonably predicted the shape of the defocus curve, especially in the intermediate vision range, but underestimated postoperative visual acuities (VAs) mainly at the defocus range between +1.0 diopters (D) and -3.5 D. The difference between predicted and achieved VA was -0.11 ± 0.13 logMAR ( P < .001) for 0.0 D defocus and -0.16 ± 0.15 D logMAR ( P < .001) for -2.50 D defocus. The shape of the CS curve was almost identical for predicted and achieved measurements, but the device underestimated the values by ≈0.3 logCS units for each spatial frequency. Visual phenomena were similar between the predicted and achieved outcome (predicted vs achieved: burst pattern 2.65 ± 0.97 degrees vs 2.74 ± 0.95 degrees, P = .63; annular pattern: 0.88 ± 0.42 degrees vs 0.93 ± 0.49 degrees, P = .59).
The device reasonably predicted the pattern of measured variables. VA/CS reduction might be attributed to viewing the objects through a more complex optical system and would need to be accounted for in clinical studies.
评估一种新型虚拟人工晶状体（IOL）植入装置预测三焦点IOL植入效果的可靠性。
西班牙和德国的临床机构。
前瞻性多中心研究。
将使用虚拟IOL（VirtIOL）装置对AT LISA tri 839MP IOL进行虚拟植入获得的术前测量结果与IOL植入后的术后（第3个月）结果进行比较。评估指标包括散焦曲线、对比敏感度（CS）（均在明视觉条件下）以及在中间视觉条件下的视觉现象（爆发和环形图案的视角大小）。
本研究纳入了45例老视非白内障患者（平均年龄56.16±5.03岁）。VirtIOL装置合理地预测了散焦曲线的形状，尤其是在中间视力范围内，但主要在+1.0屈光度（D）至-3.5 D的散焦范围内低估了术后视力（VA）。对于0.0 D散焦，预测视力与实际视力的差异为-0.11±0.13 logMAR（P<.001），对于-2.50 D散焦，差异为-0.16±0.15 D logMAR（P<.001）。预测和实际测量的CS曲线形状几乎相同，但该装置对每个空间频率的值低估了约0.3 logCS单位。预测结果与实际结果之间的视觉现象相似（预测与实际：爆发图案2.65±0.97度 vs 2.74±0.95度，P=.63；环形图案：0.88±0.42度 vs 0.93±0.49度，P=.59）。
该装置合理地预测了测量变量的模式。视力/对比敏感度降低可能归因于通过更复杂的光学系统观察物体，这在临床研究中需要加以考虑。
