Romero R, Scioscia A L, Edberg S C, Hobbins J C
Obstet Gynecol. 1986 Mar;67(3 Suppl):15S-17S. doi: 10.1097/00006250-198603001-00005.
The successful eradication of bacterial colonization of the amniotic fluid with parenteral maternal antibiotic therapy in a preterm gestation with premature rupture of membranes is reported. Amniotic fluid, obtained by amniocentesis, of a pregnancy complicated by premature rupture of membranes at 29 weeks was found to have three different bacterial species (Bacteroides bivius, Veillonella parvula, and Peptococcus). Because of prematurity and clinical quiescence, parenteral antibiotics were administered to the mother. Repeat amniocentesis was performed during treatment and 48 hours after the cessation of antibiotics failed to demonstrate bacterial growth in the amniotic fluid. Fetal lung maturity was attained, and an induction of labor was performed when antepartum heart rate testing was equivocal. This was accomplished without maternal or fetal/neonatal mishap.
据报道，在胎膜早破的早产妊娠中，通过母体胃肠外抗生素治疗成功根除了羊水细菌定植。对一名妊娠29周并发胎膜早破孕妇的羊水进行羊膜穿刺术，发现其中有三种不同的细菌（双路拟杆菌、小韦荣球菌和消化球菌）。由于早产和临床静止状态，对母亲给予了胃肠外抗生素治疗。治疗期间进行了重复羊膜穿刺术，抗生素停用48小时后，羊水未显示细菌生长。胎儿肺成熟后，当产前心率测试结果不明确时，进行了引产。引产过程中未发生母体或胎儿/新生儿不良事件。
