Kim Donghyeon, Narayanan Divyesh, Sung Shih-Hsien, Cheng Hao-Min, Chen Chen-Huan, Kim Chang-Sei, Mukkamala Ramakrishna, Hahn Jin-Oh
Mechanical Engineering, University of Maryland, College Park, MD, 20742, USA.
Bioengineering, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
NPJ Digit Med. 2024 Oct 25;7(1):301. doi: 10.1038/s41746-024-01303-5.
We investigated the potential of the transmission line model as a digital twin of aneurysmal aorta by comparatively analyzing how a uniform lossless tube-load model were fitted to the carotid and femoral artery tonometry waveforms pertaining to (i) 79 abdominal aortic aneurysm (AAA) patients vs their matched controls (CON) and (ii) 35 AAA patients before vs after endovascular aneurysm repair (EVAR). The uniform lossless tube-load model fitted the tonometry waveforms pertaining to AAA as well as CON and EVAR. In addition, the parameters in the tube-load model exhibited physiologically explainable changes: when normalized, both pulse transit time and reflection coefficient increased with AAA and decreased after EVAR, which can be explained by the increase in arterial compliance and the decrease in arterial inertance due to the aortic expansion associated with AAA. In sum, the tube-load model may have the potential as a digital twin to enable personalized AAA monitoring.
我们通过比较分析均匀无损管负载模型如何拟合与以下两类情况相关的颈动脉和股动脉压力波形，研究了传输线模型作为动脉瘤性主动脉数字孪生体的潜力：（i）79例腹主动脉瘤（AAA）患者与其匹配的对照组（CON）；（ii）35例AAA患者在血管内动脉瘤修复（EVAR）前后。均匀无损管负载模型能够很好地拟合与AAA以及CON和EVAR相关的压力波形。此外，管负载模型中的参数呈现出具有生理学解释的变化：归一化后，脉搏传播时间和反射系数均随AAA增加而增加，在EVAR后降低，这可以通过与AAA相关的主动脉扩张导致的动脉顺应性增加和动脉惯性降低来解释。总之，管负载模型可能具有作为数字孪生体实现个性化AAA监测的潜力。
