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因摄入百草枯引起的致命性纵隔气肿:一例报告。

Lethal mediastinal emphysema caused by inhalation of paraquat: a case report.

机构信息

Emergency department,Tianjin Medical University General Hospital, Tianjin, 300052, China.

出版信息

BMC Pulm Med. 2024 Oct 25;24(1):533. doi: 10.1186/s12890-024-03353-7.

DOI:10.1186/s12890-024-03353-7
PMID:39455975
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11515206/
Abstract

This paper reports on a 22-year-old male presenting with persistent chest pain accompanied by mediastinal emphysema. We firstly considered mediastinal emphysema induced by community acquired pneumonia. Pathogen detection was performed but no positive results were found. Based on the results of a subsequent lung CT scan, paraquat poisoning was suspected. Although there was no trace of paraquat in the blood, the nebulizer masks used by patient at home was found to be positive for paraquat. The diagnosis was ultimately established as paraquat poisoning via inhalation with mediastinal emphysema. This case report explores the clinical manifestations, diagnostic challenges, and treatment complexities of inhaled paraquat poisoning, emphasizing the importance of recognizing this rare poisoning route and its atypical symptoms.

摘要

这篇论文报告了一名 22 岁男性患者,他持续胸痛并伴有纵隔气肿。我们首先考虑了社区获得性肺炎引起的纵隔气肿。进行了病原体检测,但未发现阳性结果。根据随后的肺部 CT 扫描结果,怀疑为百草枯中毒。虽然血液中没有百草枯的痕迹,但在家中使用的喷雾器面罩检测出百草枯阳性。最终诊断为纵隔气肿吸入性百草枯中毒。本病例报告探讨了吸入性百草枯中毒的临床表现、诊断挑战和治疗复杂性,强调了认识这种罕见中毒途径及其非典型症状的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfc4/11515206/dd94a59fe26b/12890_2024_3353_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfc4/11515206/a254bbeb757c/12890_2024_3353_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfc4/11515206/dd94a59fe26b/12890_2024_3353_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfc4/11515206/a254bbeb757c/12890_2024_3353_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfc4/11515206/dd94a59fe26b/12890_2024_3353_Fig2_HTML.jpg

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Lethal mediastinal emphysema caused by inhalation of paraquat: a case report.因摄入百草枯引起的致命性纵隔气肿:一例报告。
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本文引用的文献

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Evaluating emergency department visits for spontaneous and traumatic pneumomediastinum: a retrospective analysis.评估自发性和外伤性纵隔气肿急诊就诊:回顾性分析。
Ulus Travma Acil Cerrahi Derg. 2024 Feb;30(2):107-113. doi: 10.14744/tjtes.2024.66059.
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Signaling pathways involved in paraquat-induced pulmonary toxicity: Molecular mechanisms and potential therapeutic drugs.百草枯诱导的肺毒性相关信号通路:分子机制与潜在治疗药物
Int Immunopharmacol. 2022 Dec;113(Pt A):109301. doi: 10.1016/j.intimp.2022.109301. Epub 2022 Oct 21.
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Dynamic changes of serum cytokines in acute paraquat poisoning and changes in patients' immune function.
急性百草枯中毒患者血清细胞因子的动态变化及其对患者免疫功能的影响。
IET Syst Biol. 2022 May;16(3-4):132-143. doi: 10.1049/syb2.12045. Epub 2022 Jun 27.
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[Spontaneous pneumomediastinum].[自发性纵隔气肿]
Rev Mal Respir. 2022 Mar;39(3):228-240. doi: 10.1016/j.rmr.2021.12.004. Epub 2022 Mar 21.
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Can kissing cause paraquat poisoning: A case report and review of literature.接吻会导致百草枯中毒吗:一例病例报告及文献综述
World J Clin Cases. 2021 Jul 16;9(20):5588-5593. doi: 10.12998/wjcc.v9.i20.5588.
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Report of a Case of Paraquat Poisoning and Mediastinal Involvement.百草枯中毒合并纵隔受累病例报告。
Adv Biomed Res. 2021 Jan 27;10:5. doi: 10.4103/abr.abr_95_20. eCollection 2021.
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Paraquat Poisoning in Children: A 5-Year Review.儿童百草枯中毒:5 年回顾。
Pediatr Emerg Care. 2021 Dec 1;37(12):e846-e849. doi: 10.1097/PEC.0000000000001868.
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Pneumomediastinum caused by occult paraquat poisoning: Case report.隐匿性百草枯中毒所致纵隔气肿:病例报告
Medicine (Baltimore). 2018 Dec;97(51):e13745. doi: 10.1097/MD.0000000000013745.
9
Clinical features and prognosis of paraquat poisoning in French Guiana: A review of 62 cases.法属圭亚那百草枯中毒的临床特征与预后:62例病例回顾
Medicine (Baltimore). 2018 Apr;97(15):e9621. doi: 10.1097/MD.0000000000009621.
10
Paraquat poisoning: Acute lung injury - a missed diagnosis.百草枯中毒:急性肺损伤——漏诊病例
S Afr Med J. 2017 Apr 25;107(5):399-401. doi: 10.7196/SAMJ.2017.v107i5.12306.