Emergency Department, Harrison International Peace Hospital, Hengshui, China.
IET Syst Biol. 2022 May;16(3-4):132-143. doi: 10.1049/syb2.12045. Epub 2022 Jun 27.
Acute paraquat poisoning is due to the extremely severe toxicity of paraquat. After paraquat enters the human body, it will cause rapid changes in the human body system. Since paraquat poisoning will quickly invade the organs of the whole body, it may cause damage to the functions of multiple organs in the poisoned patient. The liver organ is the most important detoxification site for the human body, so the damage to the liver of the patient is more obvious. This article discovers and observes the structure of paraquat and the dynamic changes of serum cytokines in patients with paraquat poisoning through the clinical phenomenon of paraquat poisoning, and the related changes of human serum cells after the subjects took paraquat and the changes of cell dynamic factors after different doses of paraquat entered the human body were analysed. At the same time, the changes in the immune function of the body of different groups of people were also observed. The experimental results in this article show that according to the intake of paraquat, the severity of poisoning patients will be mild, moderate, severe and outbreak poisoning. Among them, the dose for adults who cannot be treated for prognosis is 10 ml.
急性百草枯中毒是由于百草枯毒性极强所致。百草枯进入人体后，会引起人体系统的迅速变化。由于百草枯中毒会迅速侵袭全身各器官，可能会导致中毒患者多个器官的功能受损。肝脏器官是人体最重要的解毒部位，因此患者的肝脏受损更为明显。本文通过百草枯中毒的临床现象，发现并观察了百草枯的结构以及血清细胞因子在百草枯中毒患者中的动态变化，分析了受试者服用百草枯后人体血清细胞的相关变化以及不同剂量的百草枯进入人体后细胞动态因子的变化。同时，还观察了不同人群的身体免疫功能的变化。本文的实验结果表明，根据摄入百草枯的量，中毒患者的严重程度将从轻到重分为轻度、中度、重度和爆发性中毒。其中，无法治疗预后的成人剂量为 10ml。
