Department of Research and Development, Division of Emergencies and Critical Care, Oslo University Hospital, Oslo, Norway.
Department of Pain Management and Research, Oslo University Hospital, Oslo, Norway.
BMC Pharmacol Toxicol. 2024 Oct 25;25(1):81. doi: 10.1186/s40360-024-00805-y.
The utilization patterns of opioid analgesics and the proportion of long-term opioid use after surgery in Norway is largely unknown.
This study aimed to estimate the proportion of one-year long-term prescription opioid use among all Norwegian postoperative opioid users. Complete data from central health registries (NPR, NorPD, Statistics Norway, CoDR) were linked via the personal identification number unique to all citizens. The study period was January 1st 2010 until December 31st 2019. Long-term opioid use was defined as at least two opioid dispensings within two subsequent 90-day periods, with a minimum average use of 10 MME/day for the first 90 days.
The study population consisted of 693 495 post-operative opioid users (53.6% women), whereof 73.2% had not used opioids the year before surgery (new users). Among the postoperative opioid users, 3.8% were one-year long-term opioid users. The corresponding figures for new and previous opioid users were 0.4% and 13.1%, respectively. The highest proportions of long-term opioid use were found after transluminal endoscopy, eye surgery and assessments related to surgical procedures. In previous opioid users, the proportion of one-year long-term use was higher among women than men in all age groups, a difference that increased with age.
The proportion of postoperative long-term opioid use in Norway is generally low. We detected higher proportions of long-term opioid use after certain types of surgery, but our crude surgery definition warrants further examination. Previous opioid users pose a particular challenge in the management of postoperative pain.
The study used national health registry data from the period 2010-2019. A pre-registered analysis plan is available at Open Science Framework.
挪威术后阿片类镇痛药的使用模式和长期使用阿片类药物的比例尚不清楚。
本研究旨在估计所有挪威术后阿片类药物使用者中一年长期处方阿片类药物使用者的比例。通过个人身份证号（每个公民唯一），将中央健康登记处（NPR、NorPD、挪威统计局、CoDR）的完整数据进行链接。研究期间为 2010 年 1 月 1 日至 2019 年 12 月 31 日。长期使用阿片类药物定义为至少两次在随后的 90 天内开出处方，在前 90 天内平均使用至少 10 MME/天。
研究人群包括 693495 名术后阿片类药物使用者（53.6%为女性），其中 73.2%在手术前一年未使用阿片类药物（新使用者）。在术后阿片类药物使用者中，3.8%为一年长期阿片类药物使用者。新和以前使用阿片类药物的使用者的相应比例分别为 0.4%和 13.1%。长期使用阿片类药物的比例最高见于经内镜下血管成形术、眼部手术和与手术相关的评估。在以前使用阿片类药物的人群中，所有年龄段的女性长期使用阿片类药物的比例均高于男性，这种差异随着年龄的增长而增加。
挪威术后长期使用阿片类药物的比例总体较低。我们发现某些类型的手术后长期使用阿片类药物的比例较高，但我们的粗略手术定义需要进一步检查。以前使用阿片类药物的患者在术后疼痛管理方面构成特殊挑战。
本研究使用了 2010-2019 年期间的国家健康登记数据。在开放科学框架上可获得预先注册的分析计划。
