Levan V H, Green G M
Proc Soc Exp Biol Med. 1986 Jan;181(1):139-43. doi: 10.3181/00379727-181-42235.
Cannulas were implanted to collect bile and pancreatic juice, and the collected secretions were pumped back into the intestine at the level of the duodenum or the proximal ileum. The effect of 6 days of such treatment on pancreatic secretion and on pancreatic growth was determined. The effect on pancreatic secretion was studied by measuring the pancreatic secretory response to a stimulus, provided by acute diversion of bile-pancreatic juice from the proximal intestine. Trophic effects were studied in a separate group of rats by measuring pancreatic weight, protein content, and chymotrypsin activity after an overnight fast. Stimulated pancreatic secretion was 2.1 times greater for protein output and 3.4 times greater for fluid output in rats with chronic diversion of bile-pancreatic juice to the ileum. Pancreatic weight, protein content, and chymotrypsin activity were increased 2.6, 2.9, and 4.8 times, respectively, by chronic diversion of bile-pancreatic juice to the ileum. These results indicate that pancreatic hypertrophy and hyperplasia reported in rats with bile-pancreatic duct transposition to the ileum are the result of loss of feed-back inhibition from bile-pancreatic juice in the proximal intestine.
植入套管以收集胆汁和胰液，并将收集到的分泌物在十二指肠或回肠近端水平泵回肠道。测定了6天这种治疗对胰腺分泌和胰腺生长的影响。通过测量胰腺对来自近端肠道的胆汁胰液急性改道所提供刺激的分泌反应，研究了对胰腺分泌的影响。通过在禁食过夜后测量另一组大鼠的胰腺重量、蛋白质含量和胰凝乳蛋白酶活性，研究了其营养作用。将胆汁胰液长期改道至回肠的大鼠，刺激后的胰腺蛋白质分泌量增加2.1倍，液体分泌量增加3.4倍。将胆汁胰液长期改道至回肠后，胰腺重量、蛋白质含量和胰凝乳蛋白酶活性分别增加了2.6倍、2.9倍和4.8倍。这些结果表明，胆汁胰管转位至回肠的大鼠中报道的胰腺肥大和增生是近端肠道中胆汁胰液反馈抑制丧失的结果。
