Institute of Medical Psychology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Department of Child & Adolescent Psychiatry, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Biomolecules. 2024 Oct 16;14(10):1313. doi: 10.3390/biom14101313.
The brain and the intestinal microbiota are highly interconnected and especially vulnerable to disruptions in early life. Emerging evidence indicates that psychosocial adversity detrimentally impacts the intestinal microbiota, affecting both physical and mental health. This study aims to investigate the gut microbiome in young children in the immediate aftermath of maltreatment exposure.
Maltreatment exposure was assessed in 88 children (ages 3-7) using the Maternal Interview for the Classification of Maltreatment [MICM]. Children were allocated to three groups according to the number of experienced maltreatment categories: no maltreatment, low maltreatment, and high maltreatment exposures. Stool samples were collected and analyzed by 16S rRNA sequencing.
Children subjected to high maltreatment exposure exhibited lower alpha diversity in comparison to those with both no and low maltreatment exposure (Simpson Index, Tukey post hoc, = 0.059 and = 0.007, respectively). No significant distinctions in beta diversity were identified. High maltreatment exposure was associated with the enrichment of several genera from the class Clostridia ( and ) and the depletion of the genus (class Bacteriodia).
Severe maltreatment exposure is associated with alterations in the gut microbiota of young children. Longitudinal trajectories of intestinal microbiota composition in the context of maltreatment may reveal important insights related to psychiatric and somatic health outcomes.
大脑和肠道微生物群高度相互关联，尤其容易受到生命早期的干扰。新出现的证据表明，心理社会逆境会对肠道微生物群产生不利影响，影响身心健康。本研究旨在调查虐待暴露后幼儿的肠道微生物组。
使用母婴虐待分类访谈（MICM）评估 88 名（3-7 岁）儿童的虐待暴露情况。根据经历的虐待类别数量，将儿童分为三组：无虐待、低虐待和高虐待暴露。收集粪便样本并通过 16S rRNA 测序进行分析。
与无和低虐待暴露的儿童相比，高虐待暴露的儿童的 alpha 多样性较低（辛普森指数，Tukey 事后检验，分别为 = 0.059 和 = 0.007）。β多样性无显著差异。高虐待暴露与类群梭菌（和）的几个属的富集以及属的消耗有关（Bacteriodia 类）。
严重的虐待暴露与幼儿肠道微生物群的改变有关。在虐待背景下肠道微生物群落组成的纵向轨迹可能揭示与精神和躯体健康结果相关的重要见解。
