Department of Biology, School of Sciences and Humanities, Nazarbayev University, Astana 010000, Kazakhstan.
Laboratory of Cell Motility, National Laboratory Astana, Nazarbayev University, Astana 010000, Kazakhstan.
Biomolecules. 2024 Oct 18;14(10):1323. doi: 10.3390/biom14101323.
Neurologic disorders such as traumatic brain injury, multiple sclerosis, Alzheimer's disease, and drug-resistant epilepsy have a high socioeconomic impact around the world. Current therapies for these disorders are often not effective. This creates a demand for the development of new therapeutic approaches to treat these disorders. Recent data suggest that autoreactive naturally occurring immunoglobulins produced by subsets of B cells, called B1 B cells, combined with complement, are actively involved in the processes of restoration of neuronal functions during pathological conditions and remyelination. The focus of this review is to discuss the possibility of creating specific therapeutic antibodies that can activate and fix complement to enhance neuronal survival and promote central nervous system repair after injuries associated with many types of neurodegenerative diseases.
神经紊乱疾病，如创伤性脑损伤、多发性硬化症、阿尔茨海默病和耐药性癫痫，在全球范围内具有很高的社会经济影响。这些疾病的当前治疗方法往往效果不佳。这就需要开发新的治疗方法来治疗这些疾病。最近的数据表明，由 B1 B 细胞等亚群产生的自身反应性天然存在的免疫球蛋白与补体结合在一起，积极参与病理条件下神经元功能的恢复和髓鞘再生过程。本综述的重点是讨论是否可以创建特异性治疗性抗体，这些抗体可以激活和固定补体，以增强神经元的存活，并在与多种神经退行性疾病相关的损伤后促进中枢神经系统修复。
