De Gezelle H, Dhont M, Thiery M, Parewyck W
Acta Obstet Gynecol Scand. 1979;58(5):469-72. doi: 10.3109/00016347909154069.
Five methods for puerperal lactation inhibition were assessed in a randomized fashion. The 90 women were divided into five groups. Four of these received a pharmacologic treatment: oral stilbestrol (15 mg dd for 5 days), a diuretic compound (bendroflumethazide 15 mg dd for 5 days) by mouth, oral bromocriptine (5 mg dd for 14 days), or an intramuscular injection containing estradiol (10 mg and testosterone (200 mg) esters administered immediately after delivery. To the women in the remaining group only physical methods were applied (breast support and local infra-red waves) and they served as controls. Prolactin plasma concentrations were determined daily for five consecutive days and showed a correlation with the clinical effectiveness of the various treatment schedules. While bromocriptine reduced and stilbestrol augmented prolactin levels, both types of treatment were equally effective in preventing lactation during the observation period. Treatment with a diuretic compound or with an injection of steroids, though less effective than the first two regimens, was nevertheless significantly more efficacious than physical treatment.
以随机方式评估了五种抑制产后泌乳的方法。90名妇女被分为五组。其中四组接受药物治疗：口服己烯雌酚（每日15毫克，共5天）、口服利尿化合物（苄氟噻嗪每日15毫克，共5天）、口服溴隐亭（每日5毫克，共14天），或在分娩后立即注射含雌二醇（10毫克）和睾酮（200毫克）酯的制剂。其余组的妇女仅采用物理方法（乳房支撑和局部红外线照射），她们作为对照组。连续五天每天测定血浆催乳素浓度，结果显示其与各种治疗方案的临床效果相关。虽然溴隐亭降低了催乳素水平，己烯雌酚提高了催乳素水平，但在观察期内，这两种治疗在预防泌乳方面同样有效。使用利尿化合物或注射类固醇进行治疗，虽然不如前两种方案有效，但仍明显比物理治疗更有效。
