David A, Romem I, Lunenfeld B, Kaufman M, Serr D M
Acta Obstet Gynecol Scand. 1977;56(3):211-5. doi: 10.3109/00016347709162122.
The relationship between stilbestrol treatment and placebo treatment was studied in 2 groups of non-nursing patients. Plasma prolactin levels were evaluated in these 2 groups on day 1, 3 and 7 of the treatment, by a radioimmunoassay technique with the double antibody method using Serono hPRL kit. Our results show that prolactin values increased significantly in the stilbestrol-group and decreased in the placebo group. It seems that the main reason for "the drying up of milk" is the lack of stimulation of the nipples, which after a releatively constant time of 5--10 days will lead to decreased prolactin levels. Stilbestrol treatment is not effective in "drying up" the milk more rapidly in patients who do not want to nurse. When patients have symptoms a combination of analgesia and breast support usually brings relief within 24 to 48 hours.
在两组非哺乳期患者中研究了己烯雌酚治疗与安慰剂治疗之间的关系。在治疗的第1天、第3天和第7天，采用放射免疫分析技术，使用赛诺的人催乳素试剂盒，通过双抗体法对这两组患者的血浆催乳素水平进行了评估。我们的结果显示，己烯雌酚组的催乳素值显著升高，而安慰剂组的催乳素值下降。“回奶”的主要原因似乎是乳头缺乏刺激，在相对恒定的5 - 10天后，这将导致催乳素水平下降。对于不想哺乳的患者，己烯雌酚治疗并不能更快速有效地“回奶”。当患者出现症状时，止痛和乳房支撑相结合通常能在24至48小时内缓解症状。
