Ramos-Junior Olavo João Frederico, Pinheiro Vivian Dos Santos, Souza Tatiane Gomes Dos Santos de, Alvares Thiago Silveira
Nutrition and Exercise Metabolism Research Group, Federal University of Rio de Janeiro, Macaé 27971-525, RJ, Brazil.
Food and Nutrition Institute, Multidisciplinary Center, Federal University of Rio de Janeiro, Macaé 27930-560, RJ, Brazil.
Antioxidants (Basel). 2024 Sep 26;13(10):1175. doi: 10.3390/antiox13101175.
Aging is associated with increased reactive oxygen species (ROS) and reduced bioavailability of nitric oxide (NO). Curcumin has been shown to increase NO bioavailability due to its ability to neutralize ROS, preventing oxidative stress. The present study aimed to investigate the effect of curcumin intake on skeletal muscle oxygen parameters and exercise tolerance in response to exercise in older people. Changes in circulating levels of NO metabolites were also investigated.
Older subjects consumed 10 g of turmeric root extract from L. (containing 95.33% of the total curcuminoids) or placebo in a randomized, double-blind, crossover study. A time of 2 h after ingestion, the participants performed one set of rhythmic handgrip exercise until the limit of tolerance, followed by 5 min of recovery. During exercise and exercise recovery, skeletal muscle oxygen saturation parameters were recorded.
During exercise, the amplitude of deoxyhemoglobin was greater after curcumin intake compared to placebo (CUR: 13.11 ± 9.52 vs. PLA: 10.22 ± 8.39 μM, = 0.030). Furthermore, a faster skeletal muscle oxygen resaturation during exercise recovery was observed after curcumin compared to placebo (CUR: 1.01 ± 0.65 vs. PLA: 0.32 ± 0.20%.s, = 0.004). These results were associated with significant changes in plasma nitrite (CUR: 6.82 ± 11.68 vs. PLA: -4.94 ± 17.28%, = 0.028). There was no statistical difference in the total hemoglobin, exercise time until fatigue, and plasma nitrate between groups.
The present study suggests that curcumin improves muscle oxygenation status at the capillary level in older adults by possibly improving muscle oxygen extraction and/or delivery, with no effect on exercise tolerance.
衰老与活性氧（ROS）增加和一氧化氮（NO）生物利用度降低有关。姜黄素已被证明因其具有中和ROS的能力而能提高NO生物利用度，从而预防氧化应激。本研究旨在调查摄入姜黄素对老年人运动时骨骼肌氧参数和运动耐力的影响。同时还研究了循环中NO代谢产物水平的变化。
在一项随机、双盲、交叉研究中，老年受试者服用10克来自姜黄属植物的姜黄根提取物（含总姜黄素类化合物的95.33%）或安慰剂。摄入后2小时，参与者进行一组有节奏的握力运动直至耐受极限，随后恢复5分钟。在运动和运动恢复期间，记录骨骼肌氧饱和度参数。
运动期间，与安慰剂相比，摄入姜黄素后脱氧血红蛋白的幅度更大（姜黄素组：13.11±9.52，安慰剂组：10.22±8.39微摩尔，P = 0.030）。此外，与安慰剂相比，摄入姜黄素后在运动恢复期间观察到骨骼肌氧再饱和更快（姜黄素组：1.01±0.65，安慰剂组：0.32±0.20%·秒，P = 0.004）。这些结果与血浆亚硝酸盐的显著变化相关（姜黄素组：6.82±11.68，安慰剂组：-4.94±17.28%，P = 0.028）。两组之间的总血红蛋白、疲劳前运动时间和血浆硝酸盐无统计学差异。
本研究表明，姜黄素可能通过改善肌肉氧摄取和/或输送来改善老年人毛细血管水平的肌肉氧合状态，而对运动耐力无影响。
