Choi Youngju, Tanabe Yoko, Akazawa Nobuhiko, Zempo-Miyaki Asako, Maeda Seiji
J Exerc Nutrition Biochem. 2019 Jun 30;23(2):7-12. doi: 10.20463/jenb.2019.0010.
Eccentric exercise induces a decrease in vascular endothelial function. Curcumin, a major component of turmeric, has potent antioxidant and anti-inflammatory properties that are associated with vascular protective effects. The present study examined the effect of acute supplementation of curcumin on eccentric exercise-induced endothelial dysfunction in healthy young men.
Fourteen healthy sedentary young men (range, 21-29 years) were assigned to either the curcumin (n = 6) or placebo (n = 8) group. All subjects consumed either curcumin or placebo before exercise, and eccentric exercise of the elbow flexors was performed with their nondominant arm. Before and 60 min after exercise, brachial artery flow-mediated dilation (FMD), as an indicator of endothelial function, was measured in the non-exercised arm.
Brachial artery FMD significantly decreased following eccentric exercise (p < 0.05) in the placebo group, but acute supplementation with curcumin before exercise nullified this change. The change in FMD before and after eccentric exercise between the placebo and curcumin groups was significantly different (p < 0.05).
The present study found that acute curcumin supplementation could attenuate the decrease in endothelial function, as measured by FMD, following eccentric exercise in healthy young men.
离心运动可导致血管内皮功能下降。姜黄素是姜黄的主要成分，具有强大的抗氧化和抗炎特性，与血管保护作用相关。本研究探讨了急性补充姜黄素对健康年轻男性离心运动诱导的内皮功能障碍的影响。
14名健康久坐的年轻男性（年龄范围21 - 29岁）被分为姜黄素组（n = 6）或安慰剂组（n = 8）。所有受试者在运动前服用姜黄素或安慰剂，并用非优势手臂进行肘部屈肌的离心运动。在运动前和运动后第60分钟，在未运动的手臂上测量肱动脉血流介导的扩张（FMD），作为内皮功能的指标。
安慰剂组离心运动后肱动脉FMD显著降低（p < 0.05），但运动前急性补充姜黄素可消除这一变化。安慰剂组和姜黄素组离心运动前后FMD的变化有显著差异（p < 0.05）。
本研究发现，急性补充姜黄素可减轻健康年轻男性离心运动后通过FMD测量的内皮功能下降。
