Juesas Alvaro, Saez-Berlanga Angel, Gene-Morales Javier, Jiménez-Martínez Pablo, Alix-Fages Carlos, Fernandez-Garrido Julio, Caballero Oscar, Janicijevic Danica, Zarza Virginia, Colado Juan C
Department of Education Sciences, CEU Cardenal Herrera University, 46115 Castellón, Spain.
Research Group in Prevention and Health in Exercise and Sport (PHES), University of Valencia, 46010 Valencia, Spain.
Healthcare (Basel). 2025 May 3;13(9):1055. doi: 10.3390/healthcare13091055.
: Physical exercise and curcumin supplementation can positively influence parameters related to cognition and neuro-oxidative status. However, research on the combined effects of resistance training with elastic bands and supplementation with a curcumin-based formulation is limited. Moreover, different types of contractions (e.g., concentric and eccentric) may elicit distinct neurophysiological effects. This study evaluated the effectiveness of two high-resistance training (high-RT) programs using elastic bands in improving neuro-oxidative markers (brain-derived neurotrophic factor [BDNF] and F2-isoprostanes), cognitive function, physical performance, and quality of life, and examined the additional benefits of curcumin supplementation. : Eighty-one sedentary older adults were randomly assigned to one of the following groups: accentuated eccentric training with either a bio-optimized curcumin formulation (Aecc-Cur) or placebo (Aecc-Pla); maximum strength training with either curcumin (Max-Cur) or placebo (Max-Pla); or a control group receiving curcumin (C-Cur) or placebo (C-Pla) without training. The training groups participated in a 16-week full-body high-RT program using elastic bands. : BDNF significantly increased in Aecc-Cur and Aecc-Pla (both ≤ 0.020) but showed no changes after Max-Cur or Max-Pla (both ≥ 0.256). All other dependent variables improved similarly across training groups (all ≤ 0.50). Curcumin supplementation combined with exercise significantly reduced F2-isoprostanes in the Max-Cur group compared to Aecc-Pla, and enhanced 6-Minute Walk Test performance in Aecc-Cur and Max-Cur compared to their placebo counterparts. C-Cur showed nonsignificant changes in BDNF, F2-isoprostanes, social functioning, and vitality, while C-Pla worsened these parameters. Notably, at least half of the participants in the experimental groups exhibited clinically significant improvements in 11 of 14 dependent variables. : Both high-RT protocols led to improvements in almost all dependent variables, with the Aecc program demonstrating greater effectiveness in boosting BDNF, a key neuroprotection marker. Curcumin supplementation alone and with exercise positively influenced neuro-oxidative markers and quality of life.
体育锻炼和补充姜黄素可以对与认知和神经氧化状态相关的参数产生积极影响。然而，关于弹力带抗阻训练与基于姜黄素配方的补充剂联合作用的研究有限。此外，不同类型的收缩（如向心收缩和离心收缩）可能会引发不同的神经生理效应。本研究评估了两种使用弹力带的高抗阻训练（高-RT）方案在改善神经氧化标志物（脑源性神经营养因子[BDNF]和F2-异前列腺素）、认知功能、身体机能和生活质量方面的有效性，并研究了补充姜黄素的额外益处。
81名久坐不动的老年人被随机分配到以下组之一：使用生物优化姜黄素配方（Aecc-Cur）或安慰剂（Aecc-Pla）进行强化离心训练；使用姜黄素（Max-Cur）或安慰剂（Max-Pla）进行最大力量训练；或不进行训练但接受姜黄素（C-Cur）或安慰剂（C-Pla）的对照组。训练组参加了一项为期16周的使用弹力带的全身高-RT方案。
BDNF在Aecc-Cur和Aecc-Pla组中显著增加（均≤0.020），但在Max-Cur或Max-Pla组后无变化（均≥0.256）。所有其他因变量在各训练组中均有类似改善（均≤0.50）。与Aecc-Pla组相比，补充姜黄素并结合运动显著降低了Max-Cur组中的F2-异前列腺素，与各自的安慰剂组相比，Aecc-Cur和Max-Cur组的6分钟步行试验表现有所提高。C-Cur组在BDNF、F2-异前列腺素、社会功能和活力方面无显著变化，而C-Pla组使这些参数恶化。值得注意的是，实验组中至少一半的参与者在14个因变量中的11个上表现出临床上显著的改善。
两种高-RT方案几乎使所有因变量都得到改善，Aecc方案在提高关键神经保护标志物BDNF方面显示出更大的有效性。单独补充姜黄素以及与运动相结合对神经氧化标志物和生活质量产生了积极影响。
