Silva Aurora, Carpena Maria, Cassani Lucia, Grosso Clara, Garcia-Oliveira Paula, Delerue-Matos Cristina, Simal-Gandara Jesus, Barroso Maria Fatima, Prieto Miguel A
Universidade de Vigo, Nutrition and Bromatology Group, Department of Analytical Chemistry and Food Science, Instituto de Agroecoloxía e Alimentación (IAA)-CITEXVI, 36310 Vigo, Spain.
REQUIMTE/LAQV, Instituto Superior de Engenharia do Porto, Instituto Politécnico do Porto, Rua Dr. António Bernardino de Almeida 431, 4249-015 Porto, Portugal.
Antioxidants (Basel). 2024 Sep 30;13(10):1189. doi: 10.3390/antiox13101189.
In recent years, consumers have been increasingly interested in natural, healthier, functional foods, with a focus on sea-based products such as algae. (BB) is a macroalga that belongs to the Phaeophyceae class. These brown algae are recognized as the source of bioactive molecules of great interest to the pharmaceutical and nutraceutical industries. The present work applied response surface methodology to optimize the microwave-assisted extraction of the poorly studied algae. The optimization variables were time, pressure, and solvent composition (ethanol/water) and the response parameters selected were yield, total phenolic and flavonoid content, and the antioxidant profile by evaluating DPPH, ABTS scavenging activity, and β-carotene discoloration capacity. The results obtained reveal remarkable bioactivity of the crude extract of BB with positive results as an antioxidant and antimicrobial agent. Furthermore, the BB extract's capacity to inhibit enzymes related to neurodegenerative diseases and its anti-inflammatory and anti-proliferation activity open the possibility of future food or pharmaceutical applications.
近年来，消费者对天然、更健康的功能性食品越来越感兴趣，尤其关注以藻类等海洋产品为重点。（BB）是一种属于褐藻纲的大型海藻。这些褐藻被认为是制药和营养保健品行业极为感兴趣的生物活性分子的来源。本研究应用响应面法优化对研究较少的藻类进行微波辅助提取。优化变量为时间、压力和溶剂组成（乙醇/水），所选响应参数为产率、总酚和黄酮含量，以及通过评估DPPH、ABTS清除活性和β-胡萝卜素脱色能力得出的抗氧化特性。所得结果表明，BB粗提物具有显著的生物活性，作为抗氧化剂和抗菌剂效果良好。此外，BB提取物抑制与神经退行性疾病相关酶的能力及其抗炎和抗增殖活性为未来的食品或制药应用开辟了可能性。
