CICECO-Aveiro Institute of Materials, Chemistry Department, University of Aveiro, 3810-193 Aveiro, Portugal.
QOPNA/LAQV & REQUIMTE, Chemistry Department, University of Aveiro, 3810-193 Aveiro, Portugal.
Mar Drugs. 2019 Sep 28;17(10):556. doi: 10.3390/md17100556.
Marine resources are considered as a very promising source of bioactive molecules, and macroalgae in particular have gained special attention, due to their structurally diverse composition. Particular interest has been devoted to the brown macroalga , due to their abundance in bioactive linear diterpenes. In this appraisal, a thorough review concerning the methodologies used in the extraction, fractionation, and identification of diterpenes from is provided and discussed in detail. An exhaustive compilation of the mass spectra and nuclear magnetic resonance (NMR) data are also provided. The in vitro and assays already performed to assess different biological activities attributed to diterpenes are also reviewed, emphasizing the use of isolated components, enriched fractions, or crude extracts. The associated major strengths and challenges for the exploitation of diterpenes for high-value applications are critically discussed.
海洋资源被认为是生物活性分子的一个非常有前途的来源，特别是大型藻类，由于其结构多样的组成，引起了特别的关注。由于其丰富的生物活性线性二萜，棕色大型藻类引起了特别的关注。在这个评估中，详细提供并讨论了从 中提取、分离和鉴定二萜的方法学。还提供了详尽的质谱和核磁共振（NMR）数据汇编。还回顾了已经进行的评估归因于 的二萜的不同生物活性的体外和 测定，强调了使用分离的成分、富集的馏分或粗提取物。还批判性地讨论了用于高价值应用的 二萜开发的相关主要优势和挑战。
