丝氨酸蛋白酶抑制剂家族 B 成员 2 多态性与糖尿病肾病患者的关联研究。
Serpin Family B Member 2 Polymorphisms in Patients with Diabetic Kidney Disease: An Association Study.
机构信息
Department of Nephrology, School of Medicine, University of Thessaly, Panepistimiou 3, Biopolis, 41500 Larissa, Greece.
Ophthalmology Clinic, University of Thessaly, 41335 Larissa, Greece.
出版信息
Int J Mol Sci. 2024 Oct 10;25(20):10906. doi: 10.3390/ijms252010906.
Diabetic kidney disease (DKD) is a serious microvascular complication of type 2 diabetes mellitus (T2DM). Despite the numerous genetic loci that have been associated with the disease in T2DM, the genetic architecture of DKD remains unclear until today. In contrast to , the contribution of has not been examined in DKD. Therefore, we conducted the first genetic association study of to elucidate its role in DKD. In total, the study involved 197 patients with DKD, 155 patients with T2DM without microvascular complications (diabetic kidney disease, diabetic retinopathy, and diabetic neuropathy), and 246 healthy controls. The generalized odds ratio (OR) was calculated to estimate the risk on DKD development. The present association study regarding SNPs (rs4941230, rs3819335, rs13381217, rs6140) did not reveal any significant association between variants and DKD. Additional studies in other populations are necessary to further investigate the role of this gene in the progression of diabetes mellitus and development of DKD.
糖尿病肾病（DKD）是 2 型糖尿病（T2DM）的一种严重的微血管并发症。尽管已经在 T2DM 中发现了许多与该疾病相关的遗传位点，但 DKD 的遗传结构至今仍不清楚。与 不同， 在 DKD 中的作用尚未被研究。因此，我们进行了 与 DKD 相关的首次遗传关联研究，以阐明其在 DKD 中的作用。共有 197 名 DKD 患者、155 名无微血管并发症的 T2DM 患者（糖尿病肾病、糖尿病视网膜病变和糖尿病神经病变）和 246 名健康对照者参与了这项研究。计算广义优势比（OR）以估计 DKD 发病的风险。本研究关于 SNPs（rs4941230、rs3819335、rs13381217、rs6140）的关联研究并未显示 变体与 DKD 之间存在任何显著关联。需要在其他人群中进行进一步的研究，以进一步探讨该基因在糖尿病进展和 DKD 发展中的作用。
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