Jilin Province Engineering Laboratory of Plant Genetic Improvement, College of Plant Science, Jilin University, Changchun 130062, China.
Laboratory of Plant Molecular and Developmental Biology, Zhejiang A & F University, Hangzhou 311300, China.
Int J Mol Sci. 2022 Mar 11;23(6):3031. doi: 10.3390/ijms23063031.
In eukaryotes, the nucleus is the regulatory center of cytogenetics and metabolism, and it is critical for fundamental biological processes, including DNA replication and transcription, protein synthesis, and biological macromolecule transportation. The eukaryotic nucleus is surrounded by a lipid bilayer called the nuclear envelope (NE), which creates a microenvironment for sophisticated cellular processes. The NE is perforated by the nuclear pore complex (NPC), which is the channel for biological macromolecule bi-directional transport between the nucleus and cytoplasm. It is well known that NPC is the spatial designer of the genome and the manager of genomic function. Moreover, the NPC is considered to be a platform for the continual adaptation and evolution of eukaryotes. So far, a number of nucleoporins required for plant-defense processes have been identified. Here, we first provide an overview of NPC organization in plants, and then discuss recent findings in the plant NPC to elaborate on and dissect the distinct defensive functions of different NPC subcomponents in plant immune defense, growth and development, hormone signaling, and temperature response. Nucleoporins located in different components of NPC have their unique functions, and the link between the NPC and nucleocytoplasmic trafficking promotes crosstalk of different defense signals in plants. It is necessary to explore appropriate components of the NPC as potential targets for the breeding of high-quality and broad spectrum resistance crop varieties.
在真核生物中，细胞核是细胞遗传学和新陈代谢的调控中心，对包括 DNA 复制和转录、蛋白质合成以及生物大分子运输在内的基本生物过程至关重要。真核细胞核被称为核膜 (NE) 的脂质双层所包围，为复杂的细胞过程创造了一个微环境。NE 被核孔复合物 (NPC) 穿孔，NPC 是生物大分子在核质和细胞质之间双向运输的通道。众所周知，NPC 是基因组的空间设计师和基因组功能的管理者。此外，NPC 被认为是真核生物不断适应和进化的平台。迄今为止，已经鉴定出许多参与植物防御过程所需的核孔蛋白。在这里，我们首先概述了植物 NPC 的组织，然后讨论了植物 NPC 的最新发现，以详细阐述和剖析不同 NPC 亚基在植物免疫防御、生长发育、激素信号和温度响应中的独特防御功能。位于 NPC 不同成分中的核孔蛋白具有独特的功能，NPC 与核质转运之间的联系促进了植物中不同防御信号的串扰。有必要探索 NPC 的适当成分作为培育高质量和广谱抗性作物品种的潜在目标。
