该基因的多态性rs259983与妊娠期糖尿病孕妇的贫血风险相关。
Polymorphism rs259983 of the gene is associated with the risk of anemia in pregnant women with gestational diabetes.
作者信息
Karpova Nataliia, Dmitrenko Olga, Arshinova Ekaterina, Nurbekov Malik
机构信息
Federal State Budgetary Scientific Institution, Research Institute of General Pathology and Pathophysiology, Moscow, Russia.
出版信息
Egypt J Med Hum Genet. 2025;26(1):94. doi: 10.1186/s43042-025-00723-6. Epub 2025 Jun 3.
BACKGROUND
Iron deficiency is a cause of anemia in pregnant women. Iron metabolism is closely related to zinc levels and the state of zinc-containing proteins. Zinc-binding proteins () can also bind other metal ions. Genetic factors can also be a factor leading to unstable iron levels in the blood.
RESULTS
The aim of this study was to investigate the relationship between rs259983 of the zinc finger protein 831 () gene and anemia in pregnant women with gestational diabetes mellitus (GDM). The PCR test system with Taq-Man samples was developed for genotyping rs259983 of the gene. As a result, an association was found between rs259983 of the gene and the risk of anemia. According to in silico analysis, the protein is able to bind iron (FE, 0.69) and other ions, which may play an essential role in anemia pathogenesis.
CONCLUSIONS
Carriers of the C allele in the homozygous state rs259983 of the are at greater risk of developing anemia. Further studies are required to assess the effect of polymorphisms on the risk of pregnancy pathologies.
背景
缺铁是孕妇贫血的一个原因。铁代谢与锌水平及含锌蛋白的状态密切相关。锌结合蛋白（）也可结合其他金属离子。遗传因素也可能是导致血液中铁水平不稳定的一个因素。
结果
本研究的目的是调查锌指蛋白831（）基因的rs259983与妊娠期糖尿病（GDM）孕妇贫血之间的关系。开发了用于对基因的rs259983进行基因分型的Taq-Man样本PCR检测系统。结果发现，基因的rs259983与贫血风险之间存在关联。根据计算机模拟分析，蛋白能够结合铁（FE，0.69）和其他离子，这可能在贫血发病机制中起重要作用。
结论
基因rs259983纯合状态下的C等位基因携带者患贫血的风险更高。需要进一步研究来评估多态性对妊娠病理风险的影响。
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