Kuksin Maria, Bidault Jourdainne Valeska, Rossignol Guillaume, Aegerter Philippe, Hery Géraldine, Teglas Jean-Paul, Fouquet Virginie, Branchereau Sophie, Guérin Florent
Department of Clinical Research, Assistance Publique-Hôpitaux de Paris, Université Paris-Saclay, Bicêtre Hospital, 78 Rue du Général Leclerc, 94270 Le Kremlin Bicêtre, France.
Department of Paediatric Surgery, Hôpital Mère-Enfant, Hospices Civils de Lyon, 59 Boulevard Pinel, 69500 Bron, France.
Children (Basel). 2024 Oct 16;11(10):1248. doi: 10.3390/children11101248.
BACKGROUND/OBJECTIVES: In paediatric liver transplantation, donor-recipient compatibility depends on graft size. We explored whether the graft weight can be predicted using the donor's biometric parameters.
We used seven easily available biometric variables in 142 anonymised paediatric and adult donors, with data collected between 2016 and 2022. The whole or partial liver was transplanted in our hospital from these donors. We identified the variables that had the strongest correlation to our response variable: whole liver graft weight.
In child donors, we determined two linear models: using donor weight and height on the one hand and using donor weight and right liver span on the other hand. Both models had a coefficient of determination R = 0.86 and -value < 10. We also determined two models in adult donors using donor weight and height (R = 0.33, < 10) and donor weight and sternal height (R = 0.38, < 10). The models proved valid based on our external dataset of 245 patients from two institutions.
In clinical practise, our models could provide rapidly accessible estimates to determine whole graft dimension compatibility in liver transplantation in children and adults. Determining similar models predicting the left lobe and lateral segment weight could prove invaluable in paediatric transplantation.
背景/目的：在小儿肝移植中，供体与受体的相容性取决于移植物大小。我们探讨了是否可以使用供体的生物特征参数来预测移植物重量。
我们在142名匿名的小儿和成人供体中使用了七个易于获得的生物特征变量，数据收集于2016年至2022年之间。这些供体的全肝或部分肝脏在我们医院进行了移植。我们确定了与我们的反应变量（全肝移植物重量）相关性最强的变量。
在儿童供体中，我们确定了两个线性模型：一个使用供体体重和身高，另一个使用供体体重和右肝叶跨度。两个模型的决定系数R均为0.86，P值<0.01。我们还在成人供体中确定了两个模型，分别使用供体体重和身高（R = 0.33，P <0.01）以及供体体重和胸骨高度（R = 0.38，P <0.01）。基于我们来自两个机构的245名患者的外部数据集，这些模型被证明是有效的。
在临床实践中，我们的模型可以提供快速可得的估计值，以确定儿童和成人肝移植中全移植物尺寸的相容性。确定预测左叶和外侧段重量的类似模型在小儿移植中可能具有巨大价值。
