Abdelgalil Abobakr, Ismail Doaa, Eskander Ayman, Girgis Marian, Farouk Ahmed, Saeedi Fajr, Shazly Mohamed, Hasnoon Amera
Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo 12613, Egypt.
Department of Clinical Pathology, Military Medical Academy, Cairo 12613, Egypt.
Children (Basel). 2024 Oct 18;11(10):1259. doi: 10.3390/children11101259.
BACKGROUND/OBJECTIVES: The purpose of this study was to determine the influence of eradication on the serum level of the orally administered valproic acid (VPA) in children with idiopathic generalized epilepsy; Methods: This prospective cohort observational study included 100 children with idiopathic generalized epilepsy, recruited from a neurology clinic from May 2021 to December 2021. The patients were divided into two groups, each containing 50 children. The first group had a positive stool antigen and -related symptoms, while the second group had a negative antigen. Eradication therapy was given to the positive group. The serum level of VPA was obtained at baseline and 4 weeks after eradication therapy.
Despite there being no significant difference between the -positive and -negative groups regarding the baseline VPA serum level (79.9 ± 13.9 and 77.9 ± 13.1 mcg/mL), respectively, the serum VPA level had significantly increased after eradication therapy (99.4 ± 11 mcg/mL) ( value = 0.000), as opposed to the -negative group (85.3 ± 10.9 mcg/mL) ( value = 0.142). Furthermore, there was a statistically significant association with a negative correlation between the VPA serum level after eradication and the number of epileptic attacks per month ( value = 0.033, R value = -0.301) and the dose of VPA ( value = 0.046, R value = -0.284).
The eradication of resulted in a highly significant improvement in the serum level of the orally given VPA in children with idiopathic generalized epilepsy, as well as an indirect decrease in the frequency of epileptic events per month, allowing for dose reduction. Eradication therapy may have anticonvulsant properties and might indirectly aid in the management of epileptic activity. screening for children with idiopathic generalized epilepsy can optimize serum VPA levels, potentially leading to better seizure control. To our knowledge, this is the first study in the literature to describe the effect of eradication on the serum level of the orally administered VPA in children with idiopathic generalized epilepsy.
背景/目的：本研究旨在确定根除[某种因素]对特发性全身性癫痫患儿口服丙戊酸（VPA）血清水平的影响；方法：这项前瞻性队列观察研究纳入了2021年5月至2021年12月从一家神经科诊所招募的100名特发性全身性癫痫患儿。患者被分为两组，每组50名儿童。第一组粪便抗原呈阳性且有相关症状，而第二组抗原呈阴性。对阳性组进行根除治疗。在基线时以及根除治疗4周后获取VPA的血清水平。
尽管阳性组和阴性组的基线VPA血清水平分别为（79.9±13.9和77.9±13.1 mcg/mL），二者之间无显著差异，但根除治疗后血清VPA水平显著升高（99.4±11 mcg/mL）（P值=0.000），与之形成对比的是阴性组（85.3±10.9 mcg/mL）（P值=0.142）。此外，根除后VPA血清水平与每月癫痫发作次数之间存在统计学上显著的负相关（P值=0.033，R值=-0.301）以及与VPA剂量之间存在负相关（P值=0.046，R值=-0.284）。
根除[某种因素]导致特发性全身性癫痫患儿口服VPA的血清水平有非常显著的改善，以及每月癫痫发作频率间接降低，从而可以减少剂量。根除治疗可能具有抗惊厥特性，并且可能间接有助于癫痫活动的管理。对特发性全身性癫痫患儿进行[某种因素]筛查可以优化血清VPA水平，有可能导致更好的癫痫控制。据我们所知，这是文献中第一项描述根除[某种因素]对特发性全身性癫痫患儿口服VPA血清水平影响的研究。
