VIB Center for Inflammation Research, Ghent, Belgium.
Department of Biomedical Molecular Biology, Faculty of Sciences, Ghent University, Ghent, Belgium.
Front Immunol. 2021 Jan 28;11:584165. doi: 10.3389/fimmu.2020.584165. eCollection 2020.
Trillions of symbiotic microbial cells colonize our body, of which the larger part is present in the human gut. These microbes play an essential role in our health and a shift in the microbiome is linked to several diseases. Recent studies also suggest a link between changes in gut microbiota and neurological disorders. Gut microbiota can communicate with the brain several routes, together called the microbiome-gut-brain axis: the neuronal route, the endocrine route, the metabolic route and the immunological route. is a genus of Gram-negative bacteria colonizing the stomach, intestine and liver. Several papers show the role of in the development and progression of neurological disorders, while hardly anything is known about other species and the brain. We recently reported a high prevalence of in patients with Parkinson's disease and showed an effect of a gastric infection on the mouse brain homeostasis. Here, we discuss the potential role of in neurological disorders and how it may affect the brain the microbiome-gut-brain axis.
数以万亿计的共生微生物细胞定植于我们的体内，其中大部分存在于人类肠道中。这些微生物在我们的健康中发挥着重要作用，微生物组的改变与多种疾病有关。最近的研究还表明，肠道微生物群的变化与神经紊乱之间存在关联。肠道微生物群可以通过几种途径与大脑进行交流，这些途径统称为微生物群-肠道-大脑轴：神经元途径、内分泌途径、代谢途径和免疫途径。幽门螺杆菌是定植于胃、肠道和肝脏的革兰氏阴性菌属。有几篇论文表明幽门螺杆菌在神经紊乱的发展和进展中起作用，而对于其他幽门螺杆菌种和大脑几乎一无所知。我们最近报道了帕金森病患者中幽门螺杆菌的高患病率，并显示了胃幽门螺杆菌感染对小鼠大脑内稳态的影响。在这里，我们讨论了幽门螺杆菌在神经紊乱中的潜在作用，以及它如何通过微生物群-肠道-大脑轴影响大脑。
