Andronache Andreea Alina, Di Cosola Roberta, Evangelista Martina, Boveri Sara, Schianchi Laura, Giamberti Alessandro, Chessa Massimo
Pediatric and Congenital Heart Disease Unit, IRCCS Policlinico San Donato, 20097 San Donato Milanese, Italy.
Scientific Division, IRCCS Policlinico San Donato, 20097 San Donato Milanese, Italy.
Children (Basel). 2024 Oct 18;11(10):1262. doi: 10.3390/children11101262.
A Norwood procedure performed after 14 days of life is notably burdened by a high mortality. We analysed the real risk and which other factors influence the mortality in late Norwood procedures.
A single-centre, retrospective review of a series of consecutive patients who underwent a surgical Norwood procedure from January 2019 until December 2023. The patients' characteristics were considered to identify the factors associated with in-hospital and interstage mortality.
35 patients were included and 71% (25) of the patients underwent the Norwood procedure after 14 days of life. The median age was 27 days (6-259 days). The in-hospital mortality was 26% (9/35) with 89% (8) of the deceased being older than 15 days at the time of the surgery. Other factors that negatively affected the outcome were a restrictive interatrial septum defect (ASD) in 66% of all patients (23), the need for mechanical ventilation in 46% (16) and systemic infection prior to surgery in 43% (15).
Age at the time of Norwood was not associated with a higher risk of mortality, but other factors such as restrictive ASD, preoperative infection and the need for mechanical ventilation prior to surgery are even more important in predicting the short-term outcome.
出生14天后进行诺伍德手术的死亡率显著较高。我们分析了晚期诺伍德手术的实际风险以及其他影响死亡率的因素。
对2019年1月至2023年12月期间连续接受诺伍德手术的一系列患者进行单中心回顾性研究。考虑患者的特征以确定与住院期间和阶段间死亡率相关的因素。
纳入35例患者,71%(25例)患者在出生14天后接受了诺伍德手术。中位年龄为27天(6 - 259天)。住院死亡率为26%(9/35),89%(8例)死亡患者在手术时年龄大于15天。其他对结果产生负面影响的因素包括:66%的患者(23例)存在限制性房间隔缺损(ASD),46%(16例)需要机械通气,43%(15例)术前存在全身感染。
诺伍德手术时的年龄与较高的死亡风险无关,但其他因素,如限制性ASD、术前感染和手术前需要机械通气,在预测短期结果方面更为重要。