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津巴布韦个体和小规模采矿业矿工结核病治疗结局:利用二手数据的随访观察性研究。

Treatment Outcomes of Tuberculosis Among Artisanal and Small-Scale Miners in Zimbabwe: A Follow-Up Observational Study Using Secondary Data.

机构信息

Baines Occupational Health Services, Harare 024, Zimbabwe.

Faculty of Medicine, National University of Science and Technology, Bulawayo 029, Zimbabwe.

出版信息

Int J Environ Res Public Health. 2024 Sep 26;21(10):1282. doi: 10.3390/ijerph21101282.

DOI:10.3390/ijerph21101282
PMID:39457255
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11508004/
Abstract

In Zimbabwe, artisanal and small-scale miners (ASMs) are a key vulnerable group with high risk for tuberculosis (TB), HIV, and silicosis. The main purpose of this study was to investigate treatment outcomes of TB among ASMs. We conducted a follow-up observational study using secondary data. We analyzed data from 208 ASMs treated for TB at two occupational health clinics. We found a high treatment success rate of 87%, comparable to the national average for drug-sensitive TB. Unsuccessful outcomes were due to death (5%) and loss to follow-up (7%). Over a quarter of ASMs had unknown HIV status. Our study is the first to document treatment outcomes of TB among ASMs in Zimbabwe. Encouragingly, this study demonstrates the possibility of achieving good TB treatment outcomes even among highly mobile populations like ASMs. Further research is needed to analyze leakages across the whole TB patient pathway among ASMs. Additionally, addressing the high rate of unknown HIV statuses among ASMs is crucial to further improve overall TB treatment outcomes in this population.

摘要

在津巴布韦,个体和小规模采矿业者(ASMs)是结核病(TB)、艾滋病毒和矽肺的高风险弱势群体。本研究的主要目的是调查 ASMs 中的结核病治疗结果。我们使用二手数据进行了一项随访观察性研究。我们分析了在两家职业健康诊所接受结核病治疗的 208 名 ASMs 的数据。我们发现治疗成功率高达 87%,与国家药物敏感性结核病的平均水平相当。不成功的结果是由于死亡(5%)和失访(7%)。超过四分之一的 ASMs 艾滋病毒状况未知。我们的研究首次记录了津巴布韦 ASMs 中的结核病治疗结果。令人鼓舞的是,这项研究表明,即使在像 ASMs 这样高度流动的人群中,也有可能实现良好的结核病治疗结果。需要进一步研究来分析 ASMs 中整个结核病患者途径中的漏洞。此外,解决 ASMs 中高比例的未知艾滋病毒状况对于进一步提高该人群的整体结核病治疗结果至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b09/11508004/62ac5a128193/ijerph-21-01282-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b09/11508004/62ac5a128193/ijerph-21-01282-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b09/11508004/62ac5a128193/ijerph-21-01282-g001.jpg

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本文引用的文献

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Impact of HIV coinfection on tuberculosis treatment outcomes in Ethiopia: a systematic review and meta-analysis.艾滋病毒合并感染对埃塞俄比亚结核病治疗结局的影响:系统评价和荟萃分析。
BMJ Open. 2024 Jul 5;14(7):e087218. doi: 10.1136/bmjopen-2024-087218.
2
Prevalence, Clinical Characteristics and Determinants of Unsuccessful Treatment Outcomes Among Pulmonary Tuberculosis Patients: A 5-Year Registry-Based Retrospective Cohort Study.肺结核患者治疗结果未成功的患病率、临床特征及决定因素:一项基于登记处的5年回顾性队列研究
Patient Relat Outcome Meas. 2024 May 23;15:187-198. doi: 10.2147/PROM.S463396. eCollection 2024.
3
Health Screening Strategies for Artisanal and Small-Scale Miners for Tuberculosis, Human Immunodeficiency Virus and Silicosis: A Case of the USAID-Supported Kunda Nqob'iTB Project in Zimbabwe.
津巴布韦美国国际开发署支持的昆达 Nqob'iTB 项目中,针对手工和小规模采矿业者的结核病、人类免疫缺陷病毒和矽肺健康筛查策略。
Int J Environ Res Public Health. 2024 Jan 8;21(1):70. doi: 10.3390/ijerph21010070.
4
Knowledge, Attitudes, and Practices of Artisanal and Small-Scale Miners regarding Tuberculosis, Human Immunodeficiency Virus, and Silicosis in Zimbabwe.津巴布韦手工和小规模采矿业者在结核病、人类免疫缺陷病毒和矽肺方面的知识、态度和实践。
Int J Environ Res Public Health. 2023 Nov 27;20(23):7116. doi: 10.3390/ijerph20237116.
5
Silicosis, tuberculosis and silica exposure among artisanal and small-scale miners: A systematic review and modelling paper.个体和小规模矿工中的矽肺病、肺结核与二氧化硅暴露:一项系统综述及建模论文
PLOS Glob Public Health. 2023 Sep 21;3(9):e0002085. doi: 10.1371/journal.pgph.0002085. eCollection 2023.
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Treatment Outcomes and Associated Factors among Tuberculosis Patients from Selected Rural Eastern Cape Hospitals: An Ambidirectional Study.东开普省部分乡村医院结核病患者的治疗结果及相关因素:一项双向研究
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Silicosis and tuberculosis: A systematic review and meta-analysis.矽肺和肺结核:系统评价和荟萃分析。
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