Postgraduate Program in Health and Environment, University of Joinville Region, Rua Paulo Malschitzki, Joinville 89219-710, SC, Brazil.
Nursing Department, University of Joinville Region, Rua Paulo Malschitzki, Joinville 89219-710, SC, Brazil.
Int J Environ Res Public Health. 2024 Oct 15;21(10):1362. doi: 10.3390/ijerph21101362.
The results regarding the association of plasma docosahexaenoic acid (DHA) levels with sleep duration conflict. This study aimed to investigate the effect of oral administration of DHA on the sleep quality of Brazilian extreme preterm infants. This cohort study is part of the Joinville Docosahexaenoic Acid Study (JoiDHA) conducted with 59 infants in Joinville, Brazil. Sleep quality was assessed using the Brief Infant Sleep Questionnaire, which consists of 12 questions about the quality of sleep the week prior to its application and was answered by the parents/guardians. Of the 59 children who participated in the study, 37 (62.7%) were supplemented with DHA and 22 (37.3%) did not receive DHA. The prevalence of poor sleep quality was higher among children with the weight status at birth <50th percentile (68.2%; = 0.045) when compared to children ≥50th percentile. However, Poisson regression analysis showed that neither weight status at birth nor DHA use was associated with sleep quality, even after adjusting for the same variables. In summary, sleep quality 12-24 months after birth was not associated with DHA supplementation in very and extreme preterm infants. Additional studies that address the increase in DHA intake would be important for the understanding of the effect of this fatty acid on sleep quality.
关于血浆二十二碳六烯酸（DHA）水平与睡眠时间之间关联的结果存在争议。本研究旨在调查口服 DHA 对巴西极早产儿睡眠质量的影响。这项队列研究是巴西若因维利 DHA 研究（JoiDHA）的一部分，共有 59 名婴儿参与，来自巴西若因维利。睡眠质量使用简短婴儿睡眠问卷（Brief Infant Sleep Questionnaire）进行评估，该问卷包含 12 个关于应用前一周睡眠质量的问题，由父母/监护人回答。在参与研究的 59 名儿童中，37 名（62.7%）接受了 DHA 补充，22 名（37.3%）未接受 DHA 补充。与出生体重处于第 50 百分位及以上的儿童相比，出生体重处于第 50 百分位以下的儿童睡眠质量较差的比例更高（68.2%； = 0.045）。然而，泊松回归分析表明，无论是出生时的体重状况还是 DHA 的使用，都与睡眠质量无关，即使在调整了相同的变量后也是如此。总之，出生后 12-24 个月的睡眠质量与非常早产儿和极早产儿的 DHA 补充无关。对于理解这种脂肪酸对睡眠质量的影响，增加 DHA 摄入量的研究将是重要的。
