一项关于补充母体二十二碳六烯酸以减轻极早产儿炎症的随机试验。
A Randomized Trial of Maternal Docosahexaenoic Acid Supplementation to Reduce Inflammation in Extremely Preterm Infants.
作者信息
Valentine Christina J, Dingess Kelly A, Kleiman Jeanne, Morrow Ardythe L, Rogers Lynette K
机构信息
The University of Cincinnati, Cincinnati, OH.
Reckitt Benckiser, Evansville, IN.
出版信息
J Pediatr Gastroenterol Nutr. 2019 Sep;69(3):388-392. doi: 10.1097/MPG.0000000000002375.
Abstract
Maternal supplementation with 1000 mg/day docosahexaenoic acid (DHA) provides third trimester DHA accretion levels in breast milk for the preterm infant. We hypothesized that DHA supplementation to mothers providing breastmilk for extremely preterm infants would result in decreased inflammatory markers, in the infant. Mother/infant dyads (n = 27) were enrolled at birth and mothers were assigned to receive 200 or 1000 mg/day of DHA. Milk and plasma samples were analyzed for fatty acids and inflammatory markers. Decreases in inflammation were observed in both maternal and infant plasma and correlated with red blood cell (RBC) DHA levels. The fact that maternal DHA supplementation decreases infant markers of inflammation implies that DHA, delivered through breastmilk, has the potential to decrease inflammation in the infant.
摘要
母亲每日补充1000毫克二十二碳六烯酸（DHA）可使早产儿母乳中的DHA在孕晚期达到积累水平。我们推测，为极早产儿提供母乳的母亲补充DHA会使婴儿体内的炎症标志物减少。母婴二元组（n = 27）在出生时入组，母亲被分配接受每日200毫克或1000毫克的DHA。对母乳和血浆样本进行脂肪酸和炎症标志物分析。在母体和婴儿血浆中均观察到炎症减轻，且与红细胞（RBC）DHA水平相关。母亲补充DHA可降低婴儿炎症标志物这一事实表明，通过母乳传递的DHA有降低婴儿炎症的潜力。
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