Developmental and Educational Dynamics Research Center (CRIdee), Università Cattolica del Sacro Cuore, 20123 Milan, Italy.
Department of Psychology, Università Cattolica del Sacro Cuore, 20123 Milan, Italy.
Genes (Basel). 2024 Sep 27;15(10):1270. doi: 10.3390/genes15101270.
BACKGROUND/OBJECTIVES: The current meta-analysis looks at the effect of ethnicity on the connection between 5-HTTLPR SNPs and PTSD patients in all published genetic association studies.
In accordance with PRISMA principles, the literature was searched in PubMed, Scopus, and ScienceDirect. A consistent method was followed by two reviewers who independently chose publications for inclusion and extracted data. Using a random-effects model, a meta-analysis of the biallelic and triallelic studies was conducted in order to determine the pooled OR and the associated 95% CI. The impact estimates were corrected for minor study effects, including publication bias, using the trim-and-fill approach.
After 17 studies were deemed eligible for inclusion, the overall sample size was 8838 controls and 2586 PTSD patients, as opposed to 627 and 3524 in the triallelic meta-analysis. The results of our meta-analysis and comprehensive review do not point to a direct main effect of the 5-HTTLPR polymorphisms on PTSD. Nonetheless, preliminary data suggest that ethnicity influences the association between 5-HTTLPR and PTSD.
According to our findings, ethnicity-especially African ethnicity-has a major influence on the relationship between 5-HTTLPR and PTSD and needs to be taken into account as a crucial moderating factor in further studies.
背景/目的：本次荟萃分析着眼于已发表的所有遗传关联研究，考察 5-HTTLPR SNP 与 PTSD 患者之间关联的种族差异。
根据 PRISMA 原则，在 PubMed、Scopus 和 ScienceDirect 中检索文献。两位审稿人采用一致的方法，独立选择纳入的出版物并提取数据。采用双等位基因和三等位基因研究的随机效应模型进行荟萃分析，以确定合并的 OR 和相关的 95%CI。使用修剪填充方法校正次要研究效应（包括发表偏倚）对影响估计值的影响。
在纳入的 17 项研究中，总体样本量为 8838 名对照和 2586 名 PTSD 患者，而三等位基因荟萃分析的样本量分别为 627 名和 3524 名。我们的荟萃分析和综合综述的结果并没有直接指向 5-HTTLPR 多态性对 PTSD 的主要作用。尽管如此，初步数据表明，种族影响 5-HTTLPR 与 PTSD 之间的关联。
根据我们的发现，种族——特别是非洲裔种族——对 5-HTTLPR 和 PTSD 之间的关系有重大影响，在进一步的研究中需要将其视为一个关键的调节因素。
