Zhang Xian, Li Qing, Xia Siyuan, He Yan, Liu Yuqiang, Yang Jinlin, Xiao Xue
Department of Pathology, Sichuan University-University of Oxford Huaxi Joint Centre for Gastrointestinal Cancer, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China.
Department of Gastroenterology and Hepatology, Sichuan University-University of Oxford Huaxi Joint Centre for Gastrointestinal Cancer, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China.
Biomedicines. 2024 Oct 7;12(10):2271. doi: 10.3390/biomedicines12102271.
Proton pump inhibitors (PPIs) are some of the most commonly prescribed drugs worldwide, but there are increasing concerns about digestive complications linked to PPIs. Next-generation sequencing studies have suggested that PPIs can significantly affect the composition of the gut microbiota, which in turn may substantially contribute to the development of these complications. Recently, emerging evidence has suggested that the translocation of oral microbes into the gut may be the primary mechanism underlying the alterations in the gut microbiota induced by PPIs in the presence of gastric acid suppression and impaired oral-gut barrier function. Moreover, the significance of oral-gut microbial translocation in health and disease conditions has gained increasing recognition. Consequently, it is imperative to enhance our understanding of the functions of the oral-gut microbiota axis in digestive disorders associated with PPI therapies. This review aims to summarize current research findings and further elucidate the contribution of the oral-gut microbiota to the pathogenesis of PPI-related digestive diseases. We aim to provide a theoretical foundation for future therapeutic and preventive strategies targeting PPI-related digestive complications through modulation of the oral-gut microbiota.
质子泵抑制剂（PPIs）是全球处方量最大的药物之一，但人们越来越关注与PPIs相关的消化并发症。新一代测序研究表明，PPIs可显著影响肠道微生物群的组成，进而可能在很大程度上导致这些并发症的发生。最近，新出现的证据表明，在胃酸抑制和口肠屏障功能受损的情况下，口腔微生物向肠道的易位可能是PPIs诱导肠道微生物群改变的主要机制。此外，口肠微生物易位在健康和疾病状态中的重要性已得到越来越多的认可。因此，迫切需要加强我们对与PPI治疗相关的消化系统疾病中口肠微生物群轴功能的理解。本综述旨在总结当前的研究结果，并进一步阐明口肠微生物群对PPI相关消化系统疾病发病机制的贡献。我们旨在为未来通过调节口肠微生物群来治疗和预防PPI相关消化并发症的策略提供理论基础。
