Imhann Floris, Vich Vila Arnau, Bonder Marc Jan, Lopez Manosalva Ailine G, Koonen Debby P Y, Fu Jingyuan, Wijmenga Cisca, Zhernakova Alexandra, Weersma Rinse K
a University of Groningen and University Medical Center Groningen , Department of Gastroenterology and Hepatology , Groningen , the Netherlands.
b University of Groningen and University Medical Center Groningen Department of Genetics , Groningen , the Netherlands.
Gut Microbes. 2017 Jul 4;8(4):351-358. doi: 10.1080/19490976.2017.1284732. Epub 2017 Jan 24.
Proton pump inhibitors (PPIs), used to treat gastro-esophageal reflux and prevent gastric ulcers, are among the most widely used drugs in the world. The use of PPIs is associated with an increased risk of enteric infections. Since the gut microbiota can, depending on composition, increase or decrease the risk of enteric infections, we investigated the effect of PPI-use on the gut microbiota. We discovered profound differences in the gut microbiota of PPI users: 20% of their bacterial taxa were statistically significantly altered compared with those of non-users. Moreover, we found that it is not only PPIs, but also antibiotics, antidepressants, statins and other commonly used medication were associated with distinct gut microbiota signatures. As a consequence, commonly used medications could affect how the gut microbiota resist enteric infections, promote or ameliorate gut inflammation, or change the host's metabolism. More studies are clearly needed to understand the role of commonly used medication in altering the gut microbiota as well as the subsequent health consequences.
质子泵抑制剂（PPIs）用于治疗胃食管反流和预防胃溃疡，是世界上使用最广泛的药物之一。使用PPIs与肠道感染风险增加有关。由于肠道微生物群根据其组成不同，可能会增加或降低肠道感染风险，我们研究了使用PPIs对肠道微生物群的影响。我们发现PPIs使用者的肠道微生物群存在显著差异：与未使用者相比，他们20%的细菌分类群有统计学上的显著改变。此外，我们发现不仅是PPIs，抗生素、抗抑郁药、他汀类药物和其他常用药物也与独特的肠道微生物群特征有关。因此，常用药物可能会影响肠道微生物群抵抗肠道感染的方式、促进或改善肠道炎症，或改变宿主的新陈代谢。显然需要更多研究来了解常用药物在改变肠道微生物群方面的作用以及随后的健康后果。
