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[日内瓦的溴云。对人群样本短期影响的流行病学研究]

[Bromine cloud in Geneva. Epidemiologic study of the short-term effects on a population sample].

作者信息

Morabia A, Selleger C, Conne P, Landry J C, Fabre J

出版信息

Schweiz Med Wochenschr. 1986 Jan 4;116(1):11-8.

PMID:3945787
Abstract

In November 1984, due to an accident at a chemical plant, toxic bromine gas spread into the town of Geneva, Switzerland, at concentrations over five times the maximal admissible concentration (MAC). Monitoring of atmospheric brome concentrations allowed the determination both of the duration of exposure and the geographical area concerned. Description of the immediate measures taken at the time of the accident illustrates how mass panic reactions can be generated or controlled, and clearly shows the vital importance of an effective communication network: it was lacking in this case and caused further insecurity for the population and isolation of the hospital. Immediate and systematic data collection enabled us to carry out an "acute" epidemiological survey of the accident. It is the first report of mass bromine intoxication in the medical literature. 91 patients with symptoms of bromine exposure were seen in the outpatient and casualty departments of the cantonal Hospital, but the clinical course was mild and self-limited in nearly all cases. One patient was admitted for 24 hours. The most common symptoms were upper respiratory tract symptoms, cough and headache. In 20-30% of cases these pesisted for more than three days, and sometimes up to one month. Recording the location of patients at the time when their first symptoms occurred made it possible to define the exposed area with precision. When the initial data collected in this "acute" fashion is reliable, it should be possible to undertake more elaborate epidemiological studies at a later stage if necessary.

摘要

1984年11月,一家化工厂发生事故,有毒溴气扩散到瑞士日内瓦镇,浓度超过最大允许浓度(MAC)的五倍以上。对大气中溴浓度的监测能够确定接触时间和受影响的地理区域。对事故发生时立即采取的措施的描述说明了如何引发或控制大规模恐慌反应,并清楚地表明了有效通信网络的至关重要性:在这种情况下,通信网络缺失,导致民众更加不安,医院也被隔离。立即进行系统的数据收集使我们能够对该事故开展一次“急性”流行病学调查。这是医学文献中关于大规模溴中毒的首份报告。在州立医院的门诊和急诊部门共接诊了91名有溴接触症状的患者,但几乎所有病例的临床病程都很轻微且为自限性。一名患者住院24小时。最常见的症状是上呼吸道症状、咳嗽和头痛。20%至30%的病例这些症状持续超过三天,有时长达一个月。记录患者首次出现症状时的位置使得能够精确界定受影响区域。如果以这种“急性”方式收集的初始数据可靠,那么如有必要,在后期开展更详尽的流行病学研究应该是可行的。

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