通过两样本孟德尔随机化分析探讨2型糖尿病与念珠菌病之间的因果关系。
A Causal Relationship between Type 2 Diabetes and Candidiasis through Two-Sample Mendelian Randomization Analysis.
作者信息
Xiong Juan, Lu Hui, Jiang Yuanying
机构信息
Department of Pharmacy, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200092, China.
出版信息
Microorganisms. 2024 Sep 30;12(10):1984. doi: 10.3390/microorganisms12101984.
The potential relationship between type 2 diabetes (T2D) and candidiasis is of concern due to the respective characteristics of these conditions, yet the exact causal link between the two remains uncertain and requires further investigation. In this study, the inverse-variance-weighted (IVW) analysis indicated a significant genetic causal relationship between T2D and candidiasis ( = 0.0264, Odds Ratio [OR], 95% confidence interval [CI] = 1.1046 [0.9096-1.2996]), T2D (wide definition) and candidiasis ( = 0.0031, OR 95% [CI] = 1.1562 [0.8718-1.4406]), and severe autoimmune T2D and candidiasis ( = 0.0041, OR 95% [CI] = 1.0559 [0.9493-1.1625]). Additionally, the MR-Egger analyses showed a significant genetic causal relationship between T2D (wide definition) and candidiasis ( = 0.0154, OR 95% [CI] = 1.3197 [0.7760-1.8634]). The weighted median analyses showed a significant genetic causal relationship between severe autoimmune T2D and candidiasis ( = 0.0285, OR 95% [CI] = 1.0554 [0.9498-1.1610]). This Mendelian randomization (MR) study provides evidence for a genetic correlation between T2D and candidiasis.
由于2型糖尿病（T2D）和念珠菌病各自的特点，它们之间的潜在关系备受关注，但两者之间的确切因果联系仍不确定，需要进一步研究。在本研究中，逆方差加权（IVW）分析表明T2D与念珠菌病之间存在显著的遗传因果关系（P = 0.0264，优势比[OR]，95%置信区间[CI] = 1.1046 [0.9096 - 1.2996]），宽泛定义的T2D与念珠菌病之间存在显著的遗传因果关系（P = 0.0031，OR 95% [CI] = 1.1562 [0.8718 - 1.4406]），以及重度自身免疫性T2D与念珠菌病之间存在显著的遗传因果关系（P = 0.0041，OR 95% [CI] = 1.0559 [0.9493 - 1.1625]）。此外，MR - Egger分析表明宽泛定义的T2D与念珠菌病之间存在显著的遗传因果关系（P = 0.0154，OR 95% [CI] = 1.3197 [0.7760 - 1.8634]）。加权中位数分析表明重度自身免疫性T2D与念珠菌病之间存在显著的遗传因果关系（P = 0.0285，OR 95% [CI] = 1.0554 [0.9498 - 1.1610]）。这项孟德尔随机化（MR）研究为T2D与念珠菌病之间的遗传相关性提供了证据。
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