有氧运动可预防高脂饮食诱导的雄性小鼠脂肪组织功能障碍。
Aerobic Exercise Prevents High-Fat-Diet-Induced Adipose Tissue Dysfunction in Male Mice.
机构信息
Department of Exercise Physiology, Beijing Sport University, Beijing 100084, China.
Key Laboratory of Physical Fitness and Exercise, Ministry of Education, Beijing Sport University, Beijing 100084, China.
出版信息
Nutrients. 2024 Oct 11;16(20):3451. doi: 10.3390/nu16203451.
BACKGROUND/OBJECTIVES: This study aimed to assess the effect of aerobic exercise on capillary density and vascular smooth muscle cell (VSMC) phenotype in the visceral and subcutaneous adipose tissue of high-fat-diet (HFD) mice in order to understand the mechanisms underlying improvements in insulin resistance (IR) and chronic inflammation in adipose tissue (AT).
METHODS
Male C57BL/6J mice were divided into HFD and normal diet groups for 12 weeks and then further split into sedentary and aerobic exercise subgroups for an additional 8 weeks. Various parameters including body weight, fat weight, blood glucose, lipid profile, insulin levels, glucose tolerance, and inflammatory cytokines were evaluated.
RESULTS
Aerobic exercise reduced HFD-induced weight gain, IR, and improved lipid profiles. HFD had a minimal effect on inflammatory cytokines except in visceral adipose tissue (VAT). IR was associated with capillary density in subcutaneous adipose tissue (SAT) and VSMC phenotype in VAT. Aerobic exercise promoted anti-inflammatory responses in VAT, correlating with VSMC phenotype in this tissue.
CONCLUSIONS
Aerobic exercise can alleviate HFD-induced IR and inflammation through the modulation of VSMC phenotype in AT.
背景/目的：本研究旨在评估有氧运动对高脂肪饮食（HFD）小鼠内脏和皮下脂肪组织中毛细血管密度和血管平滑肌细胞（VSMC）表型的影响，以了解改善脂肪组织（AT）胰岛素抵抗（IR）和慢性炎症的机制。
方法
雄性 C57BL/6J 小鼠分为 HFD 和正常饮食组，喂养 12 周，然后进一步分为久坐和有氧运动亚组，进行 8 周的额外运动。评估了各种参数，包括体重、脂肪重量、血糖、血脂谱、胰岛素水平、葡萄糖耐量和炎症细胞因子。
结果
有氧运动减轻了 HFD 引起的体重增加、IR，并改善了血脂谱。HFD 对除内脏脂肪组织（VAT）外的炎症细胞因子几乎没有影响。IR 与皮下脂肪组织（SAT）中的毛细血管密度和 VAT 中的 VSMC 表型有关。有氧运动促进了 VAT 中的抗炎反应，与该组织中的 VSMC 表型相关。
结论
有氧运动可以通过调节 AT 中的 VSMC 表型来减轻 HFD 引起的 IR 和炎症。
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