亚种对儿科肠道健康和营养的影响:当前证据和未来方向。

Impact of Subspecies on Pediatric Gut Health and Nutrition: Current Evidence and Future Directions.

机构信息

Interdisciplinary Department of Medicine, Pediatric Section, Children's Hospital 'Giovanni XXIII', University of Bari "Aldo Moro", 70126 Bari, Italy.

Neonatology and Neonatal Intensive Care, Santissima Annunziata Hospital, 74123 Taranto, Italy.

出版信息

Nutrients. 2024 Oct 16;16(20):3510. doi: 10.3390/nu16203510.

Abstract

the intestinal microbiota, a complex community vital to human health, is shaped by microbial competition and host-driven selective pressures. Among these microbes, plays a crucial role in early gut colonization during neonatal stages, where subspecies () predominates and is particularly prevalent in healthy breastfed infants. as we embark on a new era in nutrition of the pediatric population, this study seeks to examine the existing understanding regarding , encompassing both preclinical insights and clinical evidence. through a narrative disceptation of the current literature, we focus on its genetic capacity to break down various substances that support its survival and dominance in the intestine. using "omics" technologies, researchers have identified beneficial mechanisms of , including the production of short-chain fatty acids, serine protease inhibitors, and polysaccharides. While declines with age and in various diseases, it remains a widely used probiotic with documented benefits for infant and child health in numerous studies. the current scientific evidence underscores the importance for ongoing research and clinical trials for a deeper understanding of 's role in promoting long-term health.

摘要

肠道微生物群是人类健康至关重要的复杂群落,它受到微生物竞争和宿主驱动的选择压力的影响。在这些微生物中,发挥着关键作用,它在新生儿期的早期肠道定植中占优势,其中亚种()占主导地位,在健康的母乳喂养婴儿中尤为普遍。随着我们进入儿科人群营养的新时代,本研究旨在检查现有的关于的理解,包括临床前的见解和临床证据。通过对当前文献的叙述性辩论,我们专注于它分解各种物质的遗传能力,这些物质支持其在肠道中的生存和优势。研究人员利用“组学”技术,确定了有益的机制,包括短链脂肪酸、丝氨酸蛋白酶抑制剂和多糖的产生。虽然随着年龄的增长和在各种疾病中下降,但它仍然是一种广泛使用的益生菌,在许多研究中都有记录证明对婴儿和儿童健康有益。目前的科学证据强调了持续研究和临床试验的重要性,以便更深入地了解在促进长期健康方面的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8ef/11510697/d036f3903c50/nutrients-16-03510-g001.jpg

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